摘要
目的研究核仁纺锤体相关蛋白1(nucleolar spindle associated proteins-1,NuSAP1)、序列相似性为83的家族A成员(FAM83A)两者表达水平与乳腺癌改良根治术后局部复发情况的关系。方法选取221例乳腺癌并行改良根治术的患者,将术后一年之内出现复发的27例患者作为观察组,其余194例未出现术后复发的患者作为对照组,对比分析两组患者体内NuSAP1、FAM83A的表达情况并且对患者复发影响因素作因素回归分析。结果两组患者的年龄对比无显著差异(P>0.05),观察组NuSAP1及FAM83A的表达水平均高于对照组,且两组肿瘤类型、肿瘤直径、TNM分期、淋巴结转移、NuSAP1、FAM83A差异具有统计学意义(P<0.05)。肿瘤类型、肿瘤直径、TNM分期、淋巴结转移、NuSAP1、FAM83A均为术后局部复发的独立影响因素(P<0.05)。根据ROC曲线获得,最佳界限以NuSAP1(0.78)、FAM83A(36.86)可获得ROC曲线下最大面积,两项联合检测结果阳性,表明乳腺癌术后局部复发与Survivin-mRNA、OTUD3-mRNA密切相关,单项检测敏感度分别63.0%、70.4%,特异度89.7%、82.8%,且两项联合检测的敏感度(77.8%)、特异度(87.9%)均高于单项检测(P<0.05)。结论NuSAP1、FAM83A与乳腺癌的发生、转移及复发都存在密切联系,对乳腺癌术后局部复发的临床诊断及预测具有预后价值。
Objective To investigate the relationship between expression levels of nucleolar spindle associated proteins-1(NuSAP1)and FAM83A(family A with sequence similarity of 83)and local recurrence after modified radical mastectomy.Methods A total of 221 patients with breast cancer undergoing modified radical surgery were selected,27 patients with recurrence within one year after surgery were selected as the observation group,and the remaining 194 patients with no recurrence after surgery were selected as the control group.The expression of NuSAP1 and FAM83A in the 2 groups were compared and analyzed,and factor regression analysis was performed on the influencing factors of patients with recurrence.Results There was no significant difference in age between the 2 groups(P>0.05).The expression levels of NuSAP1 and FAM83A in the observation group were higher than those in the control group,and there were statistically significant differences in tumor type,tumor diameter,TNM stage,lymph node metastasis,NuSAP1 and FAM83A between the 2 groups(P<0.05).Tumor type,tumor diameter,TNM stage,lymph node metastasis,NuSAP1 and FAM83A were independent factors for postoperative local recurrence(P<0.05).According to the ROC curve,the best limit was NuSAP1(0.78)and FAM83A(36.86)to obtain the maximum area under the ROC curve.The combined results of the 2 tests were positive,indicating that local recurrence of postoperative breast cancer was closely related to Survivin-mRNA and OTUD3-mRNA.The sensitivity of single test was 63.0% and 70.4%,and the specificity was 89.7% and 82.8%,respectively.The sensitivity(77.8%)and specificity(87.9%)of the two combined tests were higher than those of single test(P<0.05).Conclusion NuSAP1 and FAM83A are closely related to the occurrence,metastasis and recurrence of breast cancer,and have prognostic value for the clinical diagnosis and prediction of postoperative local recurrence of breast cancer.
作者
王晶
邱献华
WANG Jing;QIU Xianhua(Anyang Cancer Hospital,Anyang,455000)
出处
《实用癌症杂志》
2023年第6期993-996,共4页
The Practical Journal of Cancer
