摘要
心血管疾病为全球首位致死性疾病,血管重构是多种心血管疾病的病理基础。代谢紊乱,如高脂血症、高血糖等是促进血管重构发生及发展重要危险因素;然而,非酒精性脂肪性肝病(NAFLD)作为全球广泛流行的代谢性疾病之一未受到足够重视。日益增加的临床证据及机制研究结果提示NAFLD与心血管疾病的发生发展密切相关性,但关于NAFLD为心血管疾病独立危险因素的直接证据尚缺。本综述从临床研究的角度系统阐述NAFLD促进血管重构的相关证据,进一步明确NAFLD作为重要致病因素在心血管疾病中的重要意义。
Cardiovascular disease is the world's first fatal disease,and vascular remodeling is the pathological basis of a variety of cardiovascular diseases.Metabolic disorders,such as hyperlipidemia and hyperglycemia,are important risk factors for promoting the occurrence and development of vascular remodeling.However,nonalcoholic fatty liver disease(NAFLD)has not received enough attention as one of the widely prevalent metabolic diseases worldwide.Increasing clinical evidences and mechanistic findings suggest that NAFLD is closely related to the development of cardiovascular disease,but direct evidence on NAFLD as an independent risk factor for cardiovascular disease is still lacking.This review systematically expounds the relevant evidence that NAFLD promotes vascular remodeling from the perspective of clinical research,and further clarifies the significance of NAFLD as an important pathogenic factor in cardiovascular disease.
作者
徐玉
李红良
XU Yu;LI Hongliang(Dept.of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China;Institute of Model Animal,Wuhan University,Wuhan 430071,Hubei,China)
出处
《武汉大学学报（医学版）》
CAS
2023年第5期635-640,共6页
Medical Journal of Wuhan University
基金
湖北省工程研究中心创新能力建设项目(编号:2020-470111-73-03-072238)。
