摘要
目的:探讨艾司氯胺酮联合丙泊酚在儿童无痛胃镜检查的临床应用效果。方法:选取2021年3月—2022年6月于泉州市妇幼保健院·儿童医院行无痛胃镜检查的200例患儿,应用随机数表法将患儿分为观察组及对照组,各100例。对照组行丙泊酚麻醉,观察组行艾司氯胺酮联合丙泊酚麻醉,对比两组各时间点血流动力学指标、麻醉指标、疼痛评分、不良反应发生率及家属满意度。结果:麻醉前(T_(0)),两组平均动脉压(MAP)、心率(HR)及呼吸频率(RR)比较,差异无统计学意义(P>0.05);麻醉诱导后1 min(T_(1))、开始检查(T_(2))及开始检查后3 min(T_(3)),两组MAP、HR及RR较T_(0)时均下降,但观察组高于对照组,差异有统计学意义(P<0.05);结束检查(T_(4))时,两组MAP、HR及RR均较T_(0)时下降,但观察组HR高于对照组,差异有统计学意义(P<0.05)。两组意识消失时间比较,差异无统计学意义(P>0.05);观察组睁眼时间、定向力恢复时间及留观时间均优于对照组,且丙泊酚用量少于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率(4.00%)低于对照组(12.00%),差异有统计学意义(P<0.05)。观察组家属检查总满意度(96.00%)高于对照组(87.00%),差异有统计学意义(P<0.05)。结论:艾司氯胺酮联合丙泊酚在儿童无痛胃镜检查中应用效果显著,可促进检查中血流动力学稳定,减少麻醉药物用量,缩短苏醒时间,减少不良反应,安全有效。
Objective:To investigate the clinical application effect of Esketamine combined with Propofol in painless gastroscopy in children.Method:A total of 200 children who underwent painless gastroscopy in Quanzhou Women's and Children's Hospital from March 2021 to June 2022 were selected and divided into the observation group and the control group by random number table method,100 cases in each group.The control group was given Propofol anesthesia,and the observation group was given Esketamine combined with Propofol anesthesia.The hemodynamic indexes at each time point,anesthetic indexes,pain score,adverse reaction rates and family satisfaction rate of two groups were compared.Result:Before anesthesia(T_(0)),there were no significant differences in mean arterial pressure(MAP),heart rate(HR)and respiratory rate(RR)between two groups(P>0.05);at 1 min after induction of anaesthesia(T_(1)),start of examination(T_(2))and 3 min after start of examination(T_(3)),the MAP,HR,and RR in two groups decreased compared with those T0,and the observation group were higher than those in the control group,the differences were statistically significant(P<0.05);at the end of examination(T_(4)),the MAP,HR and RR in two groups decreased compared with those T_(0),but the HR in the observation group was higher than that in the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in the time of consciousness loss between two groups(P>0.05);the time to open eyes,time to regain orientation and time to stay in room in the observation group were shorter than those in the control group,and the Propofol dosage was less than that in the control group,the differences were statistically significant(P<0.05).The incidence of adverse reactions in the observation group(4.00%)was lower than that in the control group(12.00%),the difference was statistically significant(P<0.05).The total satisfaction rate of family members in the observation group(96.00%)was higher than that in the control group(87.00%),the difference was statistically significant(P<0.05).Conclusion:The application of Esketamine combined with Propofol in painless gastroscopy in children is effective,it can promote the haemodynamic stability during examination,reduce the dosage of anaesthetic drugs,shorten the awakening time and reduce the occurrence of adverse reactions,it's safe and effective.
作者
郑彬耀
蒋林娟
肖全胜
ZHENG Binyao;JIANG Linjuan;XIAO Quansheng(Quanzhou Women's and Children's Hospital,Quanzhou 362000,China;不详)
出处
《中外医学研究》
2023年第13期40-44,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
儿童无痛胃镜
艾司氯胺酮
丙泊酚
血流动力学
疼痛
复苏
Painless gastroscopy in children
Esketamine
Propofol
Haemodynamics
Pain
Resuscitation
