摘要
目的:分析腹腔镜下低位直肠癌根治保肛术治疗低位直肠癌患者的临床效果及对生活质量的影响。方法:选择2020年5月—2022年7月高州市人民医院收治的64例低位直肠癌患者,选用随机抽签法分为对照组和研究组,各32例。对照组采用传统腹会阴联合切除术(APR)治疗,研究组采用腹腔镜下低位直肠癌根治保肛术治疗。比较两组手术相关指标、肛门直肠功能、肠道菌群失调发生率、肠道功能及生活质量。结果:研究组切口长度、术后排气时间、下床时间、住院时间均短于对照组,术中出血量少于对照组,差异有统计学意义(P<0.05);术后3个月,研究组的肛管静息压(ARP)、肛管最大收缩压(MSP)、最大耐受容量(MTV)均高于对照组,差异有统计学意义(P<0.05);术后,研究组肠道菌群失调发生率为31.25%,低于对照组的65.63%,差异有统计学意义(P<0.05);术后3个月,研究组纪念斯隆—凯特林癌症中心(MSKCC)肠道功能问卷评分、欧洲癌症治疗研究组织生命质量测定量表(EORTC-QLQ-C30)评分均高于对照组,差异有统计学意义(P<0.05)。结论:腹腔镜下低位直肠癌根治保肛术治疗低位直肠癌患者,可有效改善患者各项手术指标及肛门直肠功能,降低肠道菌群失调比例,加快肠道功能恢复,改善患者生活质量。
Objective:To analyze the clinical efficacy and influence on quality of life of patients with low rectal cancer treated with laparoscopic radical anus-preserving surgery for low rectal cancer.Method:A total of 64 patients with low rectal cancer admitted to the People's Hospital of Gaozhou from May 2020 to July 2022 were selected,and divided into control group and study group based on random drawing method,with 32 cases in each group.The control group was treated with traditional combined abdominal and perineal resection(APR),and the study group was treated with laparoscopic radical anus-preserving surgery for low rectal cancer.The clinical surgical related indexes,anorectal function,incidence of intestinal microbiota imbalance,intestinal function and quality of life were compared between the two groups.Result:The incision length,postoperative exhaust time,bedtime,and hospitalization time of the study group were shorter than those of the control group,and the intraoperative bleeding volume was less than that of the control group,the differences were statistically significant(P<0.05).Three months after surgery,the anal resting pressure(ARP),anal maximum systolic pressure(MSP),and maximum tolerable volume(MTV)of the study group were higher than those of the control group,the differences were statistically significant(P<0.05).After surgery,the incidence of intestinal microbiota imbalance in the study group was 31.25%,which was lower than 65.63%in the control group,the difference was statistically significant(P<0.05).Three months after surgery,the scores of the Memorial Sloan-Kettering Cancer Center(MSKCC)intestinal function questionnaire and the European Organization for the Treatment of Cancer quality of life scale(EORTC-QLQ-C30)in the study group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Laparoscopic radical anus-preserving surgery for low rectal cancer for low rectal cancer patients can effectively improve various surgical indicators and anorectal function,reduce the proportion of intestinal microbiota imbalance,accelerate intestinal function recovery,and improve patient quality of life.
作者
陈志军
唐如通
胡丁尹
CHEN Zhijun;TANG Rutong;HU Dingyin(The People's Hospital of Gaozhou,Gaozhou 525200,China;不详)
出处
《中外医学研究》
2023年第14期153-156,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
腹腔镜
低位直肠癌根治保肛术
低位直肠癌
肛门直肠功能
肠道菌群失调
生活质量
Laparoscopy
Radical anus-preserving surgery for low rectal cancer
Low rectal cancer
Anorectal function
Intestinal microbiota imbalance
Quality of life
