摘要
目的分析替米沙坦联合骨化三醇在糖尿病肾病治疗中的应用价值。方法选取2022年1月—2023年1月甘肃省金昌市人民医院收治的120例糖尿病肾病患者,采用随机数表法分为两组,对照组(n=60)采用替米沙坦片开展治疗,研究组(n=60)于对照组基础上联合使用骨化三醇开展治疗。治疗12周后,比较两组治疗效果、肾功能、红细胞沉降率(ESR)、炎症因子水平以及不良反应情况。结果治疗后,研究组治疗总有效率为96.67%,较对照组的85.00%明显更高,差异有统计学意义(χ^(2)=4.904,P<0.05);研究组各项肾功能指标、炎症指标以及ESR均低于对照组,差异有统计学意义(P<0.05);研究组不良反应发生率为6.67%,与对照组的5.00%对比,差异无统计学意义(χ^(2)=0.151,P>0.05)。结论替米沙坦联合骨化三醇用于糖尿病肾病治疗效果理想,可有效改善患者的肾脏功能,缓解机体炎症,降低红细胞沉降率,且不良反应较低。
Objective To analyze the application value of telmisartan combined with calcitriol in the treatment of diabetes nephropathy.Methods 120 patients with diabetes nephropathy admitted to Jinchang People's Hospital of Gansu Province from January 2022 to January 2023 were selected and randomly divided into two groups.The control group(n=60)was treated with telmisartan tablets,and the study group(n=60)was treated with calcitriol on the basis of the control group.After 12 weeks of treatment,the treatment effect,renal function,erythrocyte sedimentation rate(ESR),inflammatory factor levels,and adverse reactions were compared between the two groups.Results After treatment,the total effective rate of treatment in the study group was 96.67%,significantly higher than 85.00%in the control group,with a statistically significant difference(χ^(2)=4.904,P<0.05);the indexes of renal function,inflammation,and ESR in the study group were significantly lower than those in the control group,with a statistically significant difference(P<0.05);the incidence of adverse reactions in the study group was 6.67%,which was not statistically significant compared to 5.00%in the control group(χ^(2)=0.151,P>0.05).Conclusion Telmisartan combined with calcitriol has an ideal therapeutic effect on diabetes nephropathy,which can effectively improve the renal function of patients,alleviate body inflammation,reduce erythrocyte sedimentation rate,and has low adverse reactions.
作者
王雪银
杨兵
唐凤亮
WANG Xueyin;YANG Bing;TANG Fengliang(Department of Endocrine Nephropathy,Jinchang People's Hospital,Jinchang,Gansu Province,737100 China)
出处
《糖尿病新世界》
2023年第5期186-189,共4页
Diabetes New World Magazine
关键词
糖尿病肾病
替米沙坦
骨化三醇
联合用药
Diabetes nephropathy
Telmisartan
Calcitriol
Combined medication
