摘要
抗IFN-γ自身抗体引起成人免疫缺陷,从而导致机会性致病菌感染,是最近出现的医学问题。非结核分枝杆菌(NTM)感染是抗IFN-γ自身抗体阳性患者最常见的感染,近年来抗IFN-γ自身抗体相关的NTM感染不断增多。本文就抗IFN-γ自身抗体相关NTM感染的致病机制、NTM物种、临床表现及免疫调节辅助治疗等方面作一综述,为临床医生进一步了解此病,避免误诊和漏诊,并在合理治疗等方面提供帮助。
Anti-IFN-γautoantibodies cause adult immune deficiency,leading to opportunistic bacterial infection,which is a recent medical issue.Nontuberculous mycobacterial(NTM)infection is the most common infection in patients with positive anti-IFN-γautoantibodies,and NTM infection relevant to anti-IFN-γautoantibodies has been increasing in recent years.This article reviews the pathogenic mechanism,NTM species,clinical manifestations and immunoregulation adjuvant therapy of anti-IFN-γautoantibody-associated NTM infection,aiming to help clinicians better understand this disease,avoid misdiagnosis and missed diagnosis,as well as conduct rational treatment.
作者
杨亚敏(综述)
李庭红(审校)
YANG Ya-min;LI Ting-hong(The Third Central Hospital of Tianjin,Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases,Artificial Cell Engineering Technology Research Center,Infection Management Office of Tianjin Institute of Hepatobiliary Diseases,Tianjin 300170,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2023年第6期738-742,共5页
Chinese Journal of Infection Control
