摘要
目的提出一种基于原子磁力计技术的心磁图仪,为缺血性心脏病早期诊断提供全新工具。方法基于原子磁力计技术的心磁图仪包含心磁信号测量模块、磁场屏蔽模块、心磁图仪机械结构模块、心磁信号数据处理模块以及人工智能辅助判读模块。其中,心磁信号测量模块基于原子磁力计技术进行设计,为心磁测量的核心;磁场屏蔽模块采用被动磁屏蔽和主动磁补偿相结合;心磁图仪机械结构模块包括可移动检查床、支撑固定阵列式原子磁力计的无磁龙门以及其他外部结构;心磁信号数据处理模块采用微弱信号传输及处理技术;人工智能辅助判读模块采用具备时空自注意力机制的三维卷积神经网络。最后选取1例健康志愿者以及1例经冠脉造影证实存在冠脉重度狭窄的冠心病患者对心磁图仪的检测时间、图像处理时间、图像质量等进行验证。结果健康志愿者和冠心病患者均获得清晰的心磁图,心磁图检测时间均为90 s,图像处理时间分别为5 s和6 s。冠心病患者的心脏磁场分布图显示磁场角度为76.61°,伪电流密度图显示心脏磁场对应的电流流向在T峰顶点处最大电流角度为151.51°,相较于健康志愿者均有大幅度的偏转。结论基于原子磁力计技术的心磁图仪可快速、准确完成心磁图检测,对冠心病的早期诊断具有辅助价值。
Objective To propose a magnetocardiography based on atomic magnetometer technology,and to provide a new tool for early diagnosis of ischemic heart disease.Methods The magnetocardiography based on the atomic magnetometer technology includes the magnetocardiography signal measurement module,the magnetic field shielding module,the magnetocardiography mechanical structure module,the magnetocardiography signal data processing module and the artificial intelligence auxiliary interpretation module.Among them,the magnetocardiography signal measurement module is the core of the magnetocardiography,which is designed based on the atomic magnetometer technology;the magnetic field shielding module adopts the combination of passive magnetic shielding and active magnetic compensation technology;the mechanical structure module of the magnetocardiography is mainly used to provide the movable inspection table,the non-magnetic gantry supporting the fixed array atomic magnetometer and other external structures;the magnetocardiography signal data processing module uses weak signal transmission and processing technology;artificial intelligence auxiliary interpretation module uses three-dimensional convolution neural network with spatiotemporal self-attention mechanism.Finally,Select one healthy volunteer and one coronary heart disease patient with severe coronary stenosis confirmed by coronary angiography to verify the detection time,image processing time and image quality of the magnetocardiography.Results Both healthy volunteers and patients with coronary heart disease receive clear magnetocardiogram.The detection time of magnetocardiogram is 90 s,and the image processing time is 5 s and 6 s respectively.The cardiac magnetic field distribution diagram of patients with coronary heart disease shows that the magnetic field angle is 76.61°,and the pseudo-current density diagram shows that the maximum current angle at the peak of T peak corresponding to the cardiac magnetic field is 151.51°,which has a large deflection compared with that of healthy volunteers.Conclusions The magnetocardiography based on atomic magnetometer technology can complete the detection of magnetocardiogram quickly and accurately,and has auxiliary value for the early diagnosis of coronary heart disease.
作者
屠琛琛
丁铭
蔡宾
刘琳琪
张欢
周墅
杨舒雯
马钊
宋现涛
张宏家
TU Chenchen;DING Ming;CAI Bin;LIU Linqi;ZHANG Huan;ZHOU Shu;YANG Shuwen;MA Zhao;SONG Xiantao;ZHANG Hongjia(Beijing Anzhen Hospital,Capital Medical University,Beijing 100029;Beijing Anzhen Hospital-Beijing X-Magtech Technologies Limited Joint Laboratory,Beijing 100029;School of Instrumentation and Optoelectronic Engineering,Beihang University,Beijing 100044;Beijing X-Magtech Technologies Limited,Beijing 100096)
出处
《北京生物医学工程》
2023年第3期298-304,共7页
Beijing Biomedical Engineering
基金
北京市科技新星交叉合作课题(20220484222)资助。
关键词
心磁图仪
原子磁力计
无创
无辐射
心血管病早期诊断
magnetocardiography
atomic magnetometer
noninvasive
radiation free
early diagnosis of cardiovascular disease
