摘要
目的探讨适合精神病患者的血清低密度脂蛋白胆固醇(LDL-C)计算公式。方法选取2020年1月—2022年3月我院就诊的精神病患者6236例,以实际测定LDL-C为标准,比较F公式和M公式与实际测定LDL-C的相关性、差值百分率、一致性;以2021年室内质控数据比较两种公式测量不精密度,以2020、2021两年脂类室间质评(EQA)数据比较两种公式正确度,从而选择出更适合精神病患者的LDL-C计算公式。结果两种公式与实际测定法的相关性:M公式(r=0.989,r^(2)=0.978)优于F公式(r=0.940,r^(2)=0.883);两种公式与实际测定法的差值百分率差异有统计学意义(P<0.05);一致性:根据美国国家胆固醇教育计划成人治疗组第三次报告修订版(NCEP ATPⅢ)对TG水平的分组,同一组中M公式一致性高于F公式(P<0.05);测量不精密度:F公式4.28%,M公式4.02%;正确度:M公式合格,F公式不合格。结论M公式是更适合精神病患者的血清LDL-C的计算公式,当TG≥500 mg/dL时,建议使用实际测定方法检测LDL-C。
Objective To find a suitable formula for calculating serum low density lipoprotein cholesterol(LDL-C)in psychiatric patients.Methods Based on the actual determination of LDL-C,the correlation,percentage difference and consistency of formula F and formula M with the actual determination of LDL-C were compared.The imprecision of the two formulas was compared with the indoor quality control data in 2021.The accuracy of the two formulas was compared based on lipid laboratory EQA data in 2020 and 2021,so as to select a more suitable LDL-C calculation formula for psychiatric patients.Results The correlation between the two formulas and the actual determination:M formula(r=0.989,r^(2)=0.978)was better than F formula(r=0.940,r^(2)=0.883).The percentage difference between the two formulas and the actual determination:P<0.05,the difference was statistically significant.Consistency:According to the grouping of TG levels in the third revised report of the Adult Treatment Group of the National Cholesterol Education Program(NCEP ATPⅢ).The consistency of formula M was higher than formula F in the same group.Measurement imprecision:F formula 4.28%,M formula 4.02%.Accuracy:formula M passed,formula F failed.Conclusion Formula M is more suitable for the calculation of serum LDL-C in psychiatric patients,when TG≥500 mg/dL,it is recommended to use actual determination methods for detecting LDL-C.
作者
肖飞
熊子珺
李海云
金玲芝
骆名艳
XIAO Fei;XIONG Zijun;LI Haiyun;JIN Lingzhi;LUO Mingyan(Department of Laboratory,Wudong Hospital,Wuhan 430084,China)
出处
《西部医学》
2023年第6期927-931,共5页
Medical Journal of West China
基金
2021年武汉市医学科研项目(WX21Z69)。
关键词
低密度脂蛋白胆固醇
计算公式
连续标准脂质谱
精神病患者
Low density lipoprotein cholesterol
Calculation formula
Continuous standard lipid profile
Psychiatric patients
