摘要
细胞色素450(CYP450)是以血红素为辅助基团,广泛分布于生物体内的一个B族细胞色素家族蛋白酶。其中CYP2C19参与众多内源性及外源性物质代谢。本文通过检索近年国内外相关文献,系统性概述了CYP2C19基因的多态性在冠心病患者健康管理方面的应用效果,从而更好的指导临床合理用药,规避心血管事件等不良反应的发生,以期为冠心病患者的健康管理提供依据。
Cytochrome 450(CYP450)is a family B cytochrome family protease with heme as its auxiliary group and widely distributed in the body.CYP2C19 participates in the metabolism of many endogenous and exogenous substances.This article systematically summarizes the application effects of CYP2C19 gene polymorphism in the health management in patients with coronary heart disease by searching relevant domestic and foreign literatures in recent years,so as to better guide the clinical rational use of drugs and avoid adverse effects such as cardiovascular events.Occurrence,in order to provide diagnosis and treatment basis for health management.
作者
苏丹
洪海鸥
SU Dan;HONG Haiou(Health Management Center,The First Afiliated Hospital of USTC,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 23001,Anhui,China)
出处
《健康体检与管理》
2023年第2期149-152,共4页
Journal of Health Examination and Management
基金
安徽省高等学校省级质量工程项目(编号2021jyxm1799)
中国科学技术大学校级本科质量工程重点项目(编号2021xjyxm090)
中国药学会医院药学专委会医院药学科研专项(编号CPA-Z05-ZC-2021-002)。
