摘要
目的探讨合并高钙危象的弥漫大B细胞淋巴瘤病人的临床特点,提高对该疾病的认识。方法回顾性分析临沂市人民医院于2021年11月收治的1例弥漫大B细胞淋巴瘤合并高钙危象的临床资料。结果病人经腹腔肿物穿刺活检确诊弥漫大B细胞淋巴瘤,给予利妥昔单抗+环磷酰胺+多柔比星+长春地辛+甲泼尼龙(R-CHOP)化疗,化疗次日出现恶心、嗜睡、尿频,乏力,复查血钙4.31 mmol/L,合并高钙危象,并辅以水化、碱化、大量补液、护胃保肝、降血钙等治疗,血钙下降至正常,随访未再升高,后因病情恶化放弃治疗自动出院。结论弥漫大B细胞淋巴瘤合并高钙危象少见且症状因人而异,预后不良,做到早期识别及诊断,将有利于提高这类病人的疗效。
Objective To investigate the clinical characteristics of diffuse large B-cell lymphoma(DLBCL)with high calcium crisis,and to improve the understanding of this disease.Methods The clinical data of a case of diffuse large B-cell lymphoma complicated with hypercalcemia crisis admitted to Linyi People's Hospital in November 2021 were retrospectively analyzed.Results Diffuse large B-cell lymphoma was diagnosed by abdominal biopsy of the tumor,and Rituximab+cyclophosphamide+doxorubicin+vindesine+methylprednisolone(R-CHOP)chemotherapy was given.Nausea,drowsiness,frequent urination,and fatigue occurred the next day after chemotherapy,re-examination of blood calcium was 4.31 mmol/L,the patient combined with hypercalcium crisis,and supplemented with hydration,alkalization,massive fluid replenishment,stomach and liver protection,reducing blood calcium and other treatments.After treatment,blood calcium decreased to normal,and no hypercalcemia occurred during the follow-up,then abandoned treatment due to deterioration of the condition and patient was automatically discharged.Conclusion Diffuse large B-cell lymphoma with hypercalcium crisis is rare,the symptoms vary from person to person,and the prognosis is poor.Early recognition and diagnosis will be beneficial to improve the efficacy of this kind of patients.
作者
崔颖
杜文华
刘丽丽
高冠起
CUI Ying;DU Wenhua;LIU Lili;GAO Guanqi(School of Clinical Medicine,Weifang Medical University,Weifang,Shandong 261000,China;Department of Endocrinology and Metabolic Diseases,Linyi People's Hospital,Linyi,Shandong 276000,China;Department of Pathology,Linyi People's Hospital,Linyi,Shandong 276000,China)
出处
《安徽医药》
CAS
2023年第7期1396-1399,I0003,共5页
Anhui Medical and Pharmaceutical Journal
