摘要
卒中是严重危害国民健康的重大慢性非传染性疾病,目前对于卒中的诊断主要依赖于影像学检查,尚缺乏快速、简便、有效的检测措施对疾病的发生和预后做出预判。作为红细胞异质性的参数,红细胞分布宽度(RDW)主要用于血液病的诊断。近年来,国内外多项研究也探索到RDW与缺血性卒中的发病、严重程度及预后相关,对颈内动脉粥样硬化和狭窄也有预测价值。关于RDW与动脉粥样硬化及缺血性卒中之间的关联,目前认为与炎症状态和氧化损伤有关。基于RDW的简便、廉价、易获得性和对缺血性卒中的诊治的协同价值,本文针对RDW与缺血性卒中的关系及相关机制进行综述。
Stroke is a major chronic noninfectious disease that seriously endangers the health of the population.Currently,the diagnosis of stroke mainly relies on imaging examination,and there is still a lack of rapid,simple and effective detection measures to predict the occurrence and prognosis of the disease.As a parameter of red blood cell heterogeneity,red cell distribution width(RDW)is mainly used in the diagnosis of hematologic diseases.Multiple domestic and foreign studies have also explored that RDW is associated with the onset,severity and prognosis of ischemic stroke,and also has predictive value for internal carotid atherosclerosis and stenosis.The association between RDW and atherosclerosis and ischemic stroke is currently thought to be related to inflammatory status and oxidative damage.Based on RDW′s simplicity,cheapness,accessibility and synergistic value in the diagnosis and treatment of ischemic stroke,this paper reviews the relationship between red blood cell distribution width and ischemic stroke and the related mechanisms.
作者
金燕
郑鹏(综述)
周泽芳(审校)
JIN Yan;ZHENG Peng;ZHOU Zefang(Department of Neurology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of Neurology,the First Branch of the First Affiliated Hospital of Chongqing Medical University,Chongqing 400015,China)
出处
《国际检验医学杂志》
CAS
2023年第12期1512-1517,共6页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81971296)。
