摘要
目的探讨温肾健脾定脊汤治疗强直性脊柱炎的临床疗效及对脊柱功能的影响。方法选取2018年1月—2022年1月医院收治的84例强直性脊柱炎患者,依照随机数表法分为2组。对照组采用雷公藤多甙治疗,研究组在对照组基础上另给予温肾健脾定脊汤治疗,2组治疗时间均为3个月。比较2组患者中医症状评分,临床疗效,关节疼痛评分,巴氏强直性脊柱炎病情活动指数(BASDAI),巴氏强直性脊柱炎功能指数(BASFI),红细胞沉降率(ESR)、白细胞介素1β(IL-1β)、白细胞介素17(IL-17)水平及不良反应。结果治疗后,2组中医症状评分均降低(P<0.05),且研究组更低(P<0.05);研究组总有效率高于对照组(P<0.05);治疗后,2组关节疼痛评分,BASDAI和BASFI均降低(P<0.05),且研究组更低(P<0.05);治疗后,2组ESR、IL-1β、IL-17水平均降低(P<0.05),且研究组更低(P<0.05);2组患者均未发生明显不良反应。结论温肾健脾定脊汤用于治疗强直性脊柱炎可以改善临床症状,疗效确切,同时可以改善脊柱功能,减轻炎症反应,安全可靠。
Objective To explore the clinical efficacy of Wenshen Jianpi Dingji Decoction in the treatment of ankylosing spondylitis(AS)and its influence on spinal functions.Methods A total of 84 patients with ankylosing spondylitis admitted to the hospital from January 2018 to January 2022 were selected and randomly divided into two groups.The control group was treated with Triperygium wilfordii multiglucoside,while the study group was additionally treated with the self-made Wenshen Jianpi Dingji Decoction on the basis of the control group,both for 3 months.The TCM symptom scores,clinical efficacy,joint pain scores,Bartholin AS Disease Activity Indexes(BASDAI),Bartholin AS Functional Indexes(BASFI),erythrocyte sedimentation rates(ESR),levels of interleukin-1β(IL-1β)and interleukin 17(IL-17),and adverse reactions were compared between the two groups.Results After treatment,the TCM symptom scores in both groups were decreased(P<0.05),and the study group was much lower(P<0.05).The total eff ective rate of the study group was higher than that of the control group(P<0.05).After treatment,the joint pain scores,levels of BASDAI and BASFI in both groups were decreased(P<0.05),and the study group was much lower(P<0.05).After treatment,the levels of ESR,IL-1βand IL-17 in both groups were decreased(P<0.05),and the levels in the study group were much lower(P<0.05).There were no obvious adverse reactions in both groups.Conclusion In the treatment of AS,the self-made Wenshen Jianpi Dingji Decoction can improve its clinical symptoms,achieving a defi nite curative eff ect,and it can improves spinal functions and reduce the infl ammatory responses,which is safe and reliable.
作者
秦董怀
顾振宁
薛益兴
QIN Donghuai;GU Zhenning;XUE Yixing(Department of Rheumatology and Immunology,Jiangyin Hospital of Traditional Chinese Medicine,Wuxi 214400,China)
出处
《吉林中医药》
2023年第6期698-701,共4页
Jilin Journal of Chinese Medicine
基金
江苏省自然科学基金项目(BK20201126)。
关键词
温肾健脾定脊汤
雷公藤多甙
强直性脊柱炎
Wenshen Jianpi Dingji Decoction
Triperygium wilfordii multiglucoside
ankylosing spondylitis
