摘要
目的:探讨拉莫三嗪治疗脑血管病继发性癫痫的临床效果。方法:选取2020年1月—2022年1月莘县人民医院神经内科收治的100例脑血管病继发性癫痫患者作为研究对象,根据随机数字表法分为观察组和对照组,各50例。对照组采用丙戊酸钠治疗,观察组采用拉莫三嗪治疗,比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.023)。治疗前,两组抽搐、痉挛、意识障碍、两眼发直症状评分比较,差异无统计学意义(P>0.05);治疗后,观察组抽搐、痉挛、意识障碍、两眼发直症状评分均高于对照组,差异有统计学意义(P<0.05)。治疗前,两组白细胞介素-6、肿瘤坏死因子、C反应蛋白水平比较,差异无统计学意义(P>0.05);治疗后,观察组白细胞介素-6、肿瘤坏死因子、C反应蛋白水平均低于对照组,差异有统计学意义(P<0.001)。治疗前,两组躯体功能、社会功能、角色功能、认知功能、总体健康评分比较,差异无统计学意义(P>0.05);治疗后,观察组各项生活质量评分均高于对照组,差异有统计学意义(P<0.001)。治疗前,Barthel指数、简易智力状态检查量表(MMSE)评分比较,差异无统计学意义(P>0.05);治疗后,观察组Barthel指数、MMSE评分均高于对照组,差异有统计学意义(P<0.001)。结论:拉莫三嗪治疗脑血管病继发性癫痫的效果显著,可缓解患者临床症状,降低炎性因子水平,改善生活质量,提高日常生活能力和认知功能。
Objective:To explore the clinical effect of lamotrigine in treatment of epilepsy secondary to cerebrovascular disease.Methods:A total of 100 patients with epilepsy secondary to cerebrovascular disease who were admitted to the Department of Neurology in Shenxian People's Hospital from January 2020 to January 2022 were selected as the study subjects.They were divided into control group and observation group according to random number table method,with 50 cases in each group.The control group was given sodium valproate treatment and the observation group was given lamotrigine treatment.The treatment effects of the two groups were compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.023).Before treatment,there was no significant difference in the scores of convulsions,spasm,consciousness disorder and straightness of both eyes between the two groups(P>0.05).After treatment,the scores of convulsions,spasm,consciousness disorder and straightness of both eyes in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of interleukin-6,tumor necrosis factor and C-reactive protein between the two groups(P>0.05).After treatment,the levels of interleukin-6,tumor necrosis factor and C-reactive protein in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.001).Before treatment,there were no significant differences in physical function,social function,role function,cognitive function,and overall health score between the two groups(P>0.05).After treatment,the quality of life scores in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).Before treatment,there was no significant difference in Barthel index and Mini mental State Examination(MMSE)scores(P>0.05).After treatment,the Barthel index and MMSE scores in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.001).Conclusion:Lamotrigine has a significant effect in the treatment of epilepsy secondary to cerebrovascular disease,which can relieve the clinical symptoms of patients,reduce the level of inflammatory factors,improve the quality of life,improve the ability of daily life and cognitive function.
作者
靳建华
Jin Jianhua(Shenxian People's Hospital,Liaocheng 252400,Shandong Province,China)
出处
《中国社区医师》
2023年第14期22-24,27,共4页
Chinese Community Doctors
关键词
拉莫三嗪
丙戊酸钠
脑血管病继发性癫痫
Lamotrigine
Sodium valproate
Epilepsy secondary to cerebrovascular disease
