摘要
小檗碱具有抗多种葡萄球菌、链球菌和其他球菌的作用。小檗碱能多靶点地作用于细菌,干扰糖脂代谢、氨基酸代谢、核酸代谢和蛋白质代谢,以及破坏细菌细胞膜和细胞壁结构,小檗碱不仅使细菌不易产生耐药性,而且能降低细菌对其他药物的耐药性,增强其他抗菌药物的抗菌活性。游离态小檗碱是一种弱碱,其抗菌作用远强于离子态小檗碱,因此在使用小檗碱时应尽可能使其在弱碱性环境下发挥作用。笔者综述与分析了小檗碱抗球菌的药理作用研究进展。
Berberine has the effect of resisting a variety of staphylococcus,streptococcus and other cocci.Berberine can act on bacteria with multiple targets,interfering with glucolipid metabolism,amino acid metabolism,nucleic acid metabolism and protein metabolism,as well as damaging bacterial cell membranes and wall structures.Berberine not only makes bacteria less susceptible to drug resistance,but also reduces bacterial resistance to other drugs,enhancing the antibacterial activity of other antibacterial drugs.Free berberine is a weak base with a much stronger antibacterial effect than that of ionic berberine.Therefore,when using berberine,it should take effects in a weakly alkaline environment as far as possible.In this paper,the research progress in pharmacological effects of berberine against cocci is reviewed and analyzed.
作者
张明发
沈雅琴
ZHANG Ming-fa;SHEN Ya-qin(Shanghai Meiyou Pharmaceutical Co.,Ltd.,Shanghai 201204,China)
出处
《抗感染药学》
2023年第2期109-113,共5页
Anti-infection Pharmacy
关键词
小檗碱
球菌
抗菌作用
抗菌机制
berberine
cocci
antibacterial effect
antibacterial mechanism
