摘要
目的 基于倾向性评分匹配法(PSM)分析妊娠早期胚胎停育与血清激素水平及子宫动脉血流参数的关系。方法 回顾性分析2019年5月至2021年10月于新乡医学院第三附属医院建档的675例妊娠6~12周孕妇的临床资料,根据胚胎发育情况分为正常组(563例)和胚胎停育组(112例),通过PSM对两组孕妇一般资料进行匹配后得到组间协变量均衡的样本,经logistic多因素回归分析影响妊娠早期胚胎停育的危险因素。结果 采用PSM后,两组患者共有86对匹配成功,组间不平衡的协变量达到平衡。匹配后,与正常组比较,胚胎停育组人绒毛膜促性腺激素(β-HCG)水平、甲状腺过氧化物酶抗体阳性(TPOAb^(+))率、甲状腺球蛋白抗体阳性(TGAb+)率高,雌二醇(E_(2))、孕酮(P)水平、搏动指数(PI)、阻力指数(RI)、收缩期峰值流速与舒张期最低值流速比值(S/D)低,差异有统计学意义(P<0.05)。logistic多因素回归结果显示,P、TPOAb^(+)、PI、RI、S/D是影响妊娠早期胚胎停育的危险因素,即血清激素水平、子宫动脉血流参数均与妊娠早期胚胎停育有关。结论 血清激素水平、子宫动脉血流参数与妊娠早期胚胎停育有关,临床可结合妊娠期妇女血清激素水平、子宫动脉血流参数及临床表现评估胚胎发育情况。
Objective To explore the relationship between fetal termination in early pregnancy and serum hormone levels and uterine artery blood flow parameters based on propensity score matching(PSM).Methods The clinical data of 675 pregnant women at 6-12 weeks gestation recorded in the Third Affiliated Hospital of Xinxiang Medical College from May 2019 to October 2021 were retrospectively analyzed.According to the development of embryos,they were divided into normal group(563 cases)and embryo cessation group(112 cases).PSM was used to match the general data of pregnant women in the two groups to obtain covariation-balanced samples.Logistic regression analysis was used to analyze the risk factors affecting embryo termination in early pregnancy.Results After using PSM,a total of 86 pairs of patients in the two groups were successfully matched,and the imbalanced covariates between the groups reached equilibrium.Compared with the normal group,the chorionic gonadotropin(β-HCG)level,thyroid peroxidase antibody positive(TPOAb^(+))rate and thyroglobulin positive(TGAb^(+))rate were higher,estradiol(E_(2))and progesterone(P)levels,beat index(PI),resistance index(RI),and the ratio of systolic peak flow velocity to diastolic lowest flow velocity(S/D)were lower in the embryo termination group after matching.The differences among all groups were statistically significant(P<0.05).Logistic regression showed that P,TPOAb^(+),PI,RI and S/D were the risk factors affecting embryo termination in early pregnancy.Serum hormone level and uterine artery blood flow parameters were related to embryo termination in early pregnancy.Conclusion Serum hormone levels and uterine artery blood flow parameters are associated with embryo termination in early pregnancy.Clinical evaluation of fetal development can be combined with serum hormone levels,uterine artery blood flow parameters and clinical manifestations of pregnant women.
作者
赵靖雅
ZHAO Jingya(Department of Obstetrics and Gynecology,the Third Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China)
出处
《河南医学研究》
CAS
2023年第11期1983-1986,共4页
Henan Medical Research
关键词
妊娠早期胚胎停育
子宫动脉血流参数
倾向性评分匹配法
血清激素
回顾性研究
early gestation of embryo
uterine artery blood flow parameters
propensity score matching method
serum hormone
retrospective study
