摘要
目的:探究替罗非班联合机械取栓对急性前循环脑梗死患者血管再通率及短期预后的影响。方法:将2018年8月至2022年7月江南大学附属医院收治的85例急性前循环脑梗死患者按治疗方式不同分为对照组(机械取栓治疗;n=41)与研究组(替罗非班联合机械取栓治疗;n=44)。观察2组临床疗效及短期预后情况,并比较治疗前、后2组血液流变学指标、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分及日常生活能力改良Barthel指数(modified Barthel index,MBI)评分。结果:研究组血管再通率为90.91%,高于对照组的70.73%(P<0.05);2组治疗后红细胞比容、血浆黏度及全血高切黏度均低于治疗前,且研究组低于对照组(均P<0.05);2组治疗后NIHSS评分低于治疗前,MBI评分高于治疗前,且研究组优于对照组(均P<0.05);研究组治疗后90 d预后良好率为68.18%,高于对照组的43.90%(P<0.05);治疗后90 d内,2组颅内出血、再闭塞发生率与病死率比较差异均无统计学意义(均P>0.05)。结论:替罗非班联合机械取栓治疗急性前循环脑梗死的血管再通率更高,有利于短期预后。
Objective:To explore the effect of tirofiban combined with mechanical thrombectomy on vascular revascularization rate and short-term prognosis in patients with acute anterior circulation cerebral infarction.Methods:Eighty-five patients with acute anterior circulation cerebral infarction admitted in the Affiliated Hospital of Jiangnan University from August 2018 to July 2022 were divided into a control group(mechanical thrombectomy;n=41)and a study group(tirofiban combined with mechanical thrombectomy;n=44)according to the treatment method.The clinical efficacy and short-term prognosis of the 2 groups were observed.The hemorheology indexes,National Institutes of Health Stroke Scale(NIHSS)score,and daily living ability modified Barthel index(MBI)score were compared between the 2 groups before and after the treatment.Results:The vascular recanalization rate in the study group was 90.91%,which was higher than 70.73%in the control group(P<0.05).After treatment,the hematocrit,plasma viscosity and whole blood high shear viscosity of the 2 groups were lower than those before the treatment,and the study group was lower than the control group(all P<0.05).After treatment,the NIHSS scores of the 2 groups were lower than that before the treatment,and the MBI scores were higher than that before the treatment,and the study group was better than the control group(all P<0.05).The good prognosis rate in the study group at 90 days after the treatment was 68.18%,which was higher than 43.90%in the control group(P<0.05).Within 90 days after the treatment,there were no differences in the incidence of intracranial hemorrhage,vascular re-occlusion,and mortality between the 2 groups(all P>0.05).Conclusion:Tirofiban combined with mechanical thrombectomy in the treatment of acute anterior circulation cerebral infarction shows a higher vascular recirculation rate,which is beneficial to short-term prognosis.
作者
费娜
李超生
桂树华
FEI Na;LI Chaosheng;GUI Shuhua(Department of Neurology,Affiliated Hospital of Jiangnan University,Wuxi Jiangsu 214000,China)
出处
《临床与病理杂志》
CAS
2023年第4期711-717,共7页
Journal of Clinical and Pathological Research
基金
无锡市卫生健康委面上项目(MS201955)。
关键词
急性前循环脑梗死
替罗非班
机械取栓
血管再通率
预后
acute anterior circulation cerebral infarction
tirofiban
mechanical thrombectomy
vascular recirculation rate
prognosis
