摘要
胃肠-神经内分泌肿瘤是消化道肿瘤的重要组成部分,随着诊断技术提升与认识深入,其确诊率逐渐提高。胃肠-神经内分泌肿瘤属少见肿瘤,临床诊断困难,容易误诊、漏诊,治疗方式也不规范。近年胃肠-神经内分泌肿瘤诊治取得进展,特别是病理学、影像诊断、核素治疗、靶向治疗和免疫治疗方面,提高了胃肠-神经内分泌肿瘤的诊断率及疗效。文章总结了其流行病学、病理诊断、影像诊断、手术治疗、靶向治疗、放射性核素治疗、化疗、免疫治疗等方面的研究进展,将胃肠-神经内分泌肿瘤的治疗区分为转移性与非转移性两类,以期对指导临床诊疗和研发新的治疗方案有所帮助。
Gastrointestinal neuroendocrine neoplasm(GI-NEN)is an important part of digestive system tumor.With the progress of diagnosis and the further understanding of GI-NEN,the diagnostic rate is increasing.However,GI-NEN is a rare tumor,thus clinicians are not familiar with the diagnosis and treatment.Misdiagnosis and missed diagnosis of GI-NEN often occur,and the treatment regimen is not standardized.In recent years,some progresses of the diagnosis and treatment have been made in GI-NEN,especially in the aspects of pathology,imaging diagnosis,radionuclide therapy,targeted therapy and immunotherapy,which have improved the diagnosis rate and efficacy for GI-NEN.This paper reviews recent literatures of GI-NEN,summarizes its epidemiology,pathological diagnosis,image diagnosis,surgery,targeted therapy,radionuclide therapy,chemotherapy,immunotherapy,and separates GI-NEN into metastatic and non-metastatic groups for detailed review to provide a reference for guiding clinical diagnosis and treatment as well as exploring the new treatment regimens of GI-NEN.
作者
何苗
范晶
王子卫
张寿儒
He Miao;Fan Jing;Wang Ziwei;Zhang Shouru(Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Gastrointestinal Cancer Center,Chongqing University Cancer Hospital,Chongqing 400030,China;Department of Critical Care Medicine,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China;Department of General Surgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《肿瘤研究与临床》
CAS
2023年第4期309-313,共5页
Cancer Research and Clinic
关键词
癌
神经内分泌
十二指肠肿瘤
诊断
肿瘤治疗方案
Carcinoma,neuroendocrine
Duodenal neoplasms
Diagnosis
Antineoplastic protocols
