摘要
目的:研究郑州市地区60岁及以上复治肺结核患者耐药特点及影响因素,为临床结核病防治提供参考.方法:采用横断面调查设计,选取2021年1月—12月郑州市地区60岁以上的复治肺结核患者208例为研究对象,分析老年复治肺结核患者的耐药率,根据药物敏感性试验结果分为耐药组和敏感组.另收集患者的临床特点资料、胸部CT检查结果及各项实验室检查指标,通过Logistic回归分析60岁及以上复治肺结核患者发生耐多药的相关因素.结果:208例60岁及以上的复治肺结核患者中,耐药患者85例(40.87%),其中耐多药21例,多耐药28例,单耐药36例.耐药组和敏感组性别、年龄、体重指数(BMI)、高血压、糖尿病、肺野数比较,差异无统计学意义(P>0.05);耐药组居住地、既往用药不规律、既往治疗中断、肺结核空洞与敏感组比较,差异有统计学意义(P<0.05);经Logistic回归分析发现,既往用药不规律、既往治疗中断、肺结核空洞均是60岁及以上复治肺结核病患者发生耐药的危险因素(OR>1,P<0.05),居住地(城市)是60岁及以上复治肺结核病患者发生耐药的保护因素(OR<1,P<0.05).结论:郑州市地区60岁及以上复治肺结核患者耐药率较高,其中居住地、既往用药不规律、既往治疗中断、肺结核空洞均是复治肺结核病患者发生耐药的影响因素.
Objective:To study the drug resistance characteristics and influencing factors of retreated pulmonary tuberculosis patients over 60 years old in Zhengzhou,and to provide reference for clinical tuberculosis prevention and treatment.Methods:A cross-sectional survey design was used to select 208 retreated pulmonary tuberculosis patients over 60 years old in Zhengzhou City from January 2021 to December 2021 as the research object.The drug resistance rate of elderly retreated pulmonary tuberculosis patients was analyzed.According to the results of drug sensitivity test,they were divided into drug resistance group and sensitive group.In addition,the clinical characteristics,chest CT examination results and laboratory examination indexes of the patients were collected.Logistic regression was used to analyze the related factors of multidrug resistance in patients with retreated pulmonary tuberculosis aged 60 years and above.Results:Among 208 retreatment pulmonary tuberculosis patients over 60 years old,85 patients(40.87%)were drug-resistant,including 21 patients of multidrug resistance,28 patients of multidrug resistance and 36 patients of single drug resistance.There was no significant difference in gender,age,body mass index(BMI),hypertension,diabetes,and number of lung fields between the drug-resistant group and the sensitive group(P>0.05).There were statistically significant differences in residence,irregular medication,previous treatment interruption,and pulmonary tuberculosis cavity between the drug-resistant group and the sensitive group(P<0.05).Logistic regression analysis showed that irregular past drug use,previous treatment interruption,and pulmonary tuberculosis cavity were risk factors for drug resistance in retreated tuberculosis patients over 60 years old(OR>1,P<0.05),and residence(city)was a protective factor for drug resistance in retreated tuberculosis patients over 60 years old(OR<1,P<0.05).Conclusion:The drug resistance rate of retreated pulmonary tuberculosis patients over 60 years old in Zhengzhou is high,among which the residence,irregular drug use,interruption of previous treatment,and pulmonary tuberculosis cavity are the influencing factors for drug resistance of retreated pulmonary tuberculosis patients.
作者
李欣锦
王姣峰
LI Xinjin;WANG Jiaofeng(School of Public Health,Zhengzhou University,Zhengzhou 450001,Henan,China;Department of Pharmacy,Henan Provincial People's Hospital,Zhengzhou 450001,Henan,China)
出处
《中国药物滥用防治杂志》
CAS
2023年第5期786-790,共5页
Chinese Journal of Drug Abuse Prevention and Treatment
关键词
复治
结核病
抗多种药物性
影响因素
Retreatment
Tuberculosis
Resistance to multiple drugs
Influence factor
