摘要
急性心肌梗死因其高发病率及高死亡率严重危害居民健康,再灌注策略是急性心肌梗死的首选治疗策略,这些治疗措施能够快速恢复缺血心肌的血液循环,以挽救濒死的心肌细胞,减少心肌梗死面积,降低死亡率。然而再灌注可能会导致额外心脏损伤,即心肌缺血再灌注损伤(MIRI)。因此,如何减轻心肌缺血再灌注损伤成为心血管治疗急需解决的问题之一,中医药在治疗MIRI方面具有多成分、多途径、多靶点的优势,能为减轻心肌缺血再灌注损伤提供新的思路。腺苷酸活化蛋白激酶(AMPK)与MIRI密切相关,其可以通过调控炎症反应、氧化应激、自噬、凋亡和铁死亡等过程在减轻MIRI中发挥着重要作用。故该文综述了AMPK信号通路的基本结构及其在心肌缺血再灌注损伤中的作用,以及目前中医药通过调控AMPK通路治疗MIRI的研究进展,以期为心肌缺血再灌注损伤的防治提供一定的理论基础。
Due to its high incidence and mortality rate,acute myocardial infarction poses a serious threat to public health.Reperfusion therapy is the preferred treatment strategy for acute myocardial infarction,which can quickly restore blood circulation to the ischemic myocardium,rescue dying myocardial cells,reduce infarct size,and lower the mortality rate.However,reperfusion may lead to additional heart damage,known as myocardial ischemia-reperfusion injury(MIRI).Therefore,how to alleviate MIRI has become one of the urgent issues in cardiovascular therapy.Traditional Chinese medicine(TCM)has the advantage of multiple components,multiple pathways,and multiple targets in the treatment of MIRI,providing new ideas for reducing MIRI.Adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)is closely related to MIRI,and it plays an important role in alleviating MIRI by regulating inflammation,oxidative stress,autophagy,apoptosis,and ferroptosis.This article reviewed the basic structure of the AMPK signaling pathway and its role in MIRI,as well as the research progress of TCM in the treatment of MIRI by regulating the AMPK pathway,aiming to provide a theoretical basis for the prevention and treatment of MIRI.
作者
胡雅琪
刘建和
HU Yaqi;LIU Jianhe(Hunan University of Chinese Medicine,Changsha 410208,China;The First Hospital of Hunan University of Chinese Medicine,Changsha 410007,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第13期213-221,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
湖南省教育厅科学研究重点项目(21A0234)
长沙市自然科学基金项目(kq2202450)。
关键词
腺苷酸活化蛋白激酶(AMPK)信号通路
中医药
心肌缺血再灌注损伤
研究进展
adenosine 5'-monophosphate(AMP)-activated protein kinase(AMPK)signaling pathway
traditional Chinese medicine
myocardial ischemia reperfusion injury
research progress
