摘要
目的:探讨肺炎支原体肺炎(mycoplasma pneumoniae pneumonia,MPP)患儿肺泡灌洗液中半乳糖凝集素-3(galectin-3,Gal-3)、白细胞介素-33(interleukin-33,IL-33)、肺炎支原体(MP)-DNA载量、中性粒细胞比例水平及临床意义。方法:选取2020年1月至2022年3月在我院治疗的MPP患儿102例作为观察组,其中轻症患儿59例,重症患儿43例,同时选取因支气管异物就诊患儿60例作为对照组,比较各组肺泡灌洗液中Gal-3、IL-33、MP-DNA载量、中性粒细胞等差异。同时分析观察组治疗前后肺泡灌洗液中Gal-3、IL-33、MP-DNA载量、中性粒细胞等变化。结果:观察组肺泡灌洗液Gal-3、IL-33、MP-DNA载量、中性粒细胞和巨噬细胞分别为(18.82±3.10)pg/mL、(20.01±3.43)pg/mL、(5.94±1.01)log copy/mL、(18.21±3.11)%和(88.14±9.92)%,明显高于对照组(P<0.05)。观察组重症患儿肺泡灌洗液Gal-3、IL-33、MP-DNA载量、中性粒细胞分别为(20.32±3.02)pg/mL、(22.03±3.05)pg/mL、(7.07±1.70)log copy/mL和(20.31±2.88)%,明显高于轻症患儿(P<0.05)。观察组轻症和重症患儿治疗后肺泡灌洗液Gal-3、IL-33、MP-DNA载量、中性粒细胞和巨噬细胞较治疗前降低(P<0.05)。肺泡灌洗液Gal-3、IL-33、中性粒细胞与MP-DNA载量呈正相关(P<0.05),其余未见明显相关性。结论:MPP患儿肺泡灌洗液中Gal-3、IL-33、MP-DNA载量及中性粒细胞比例明显升高,与患儿病情严重程度有关,同时肺泡灌洗液中Gal-3、IL-33、中性粒细胞与MP-DNA载量呈正相关。
Objective:To investigate the levels of galectin-3(Gal-3),interleukin-33(IL-33),Mycoplasma pneumoniae(MP)-DNA,neutrophil proportion and clinical significance in alveolar lavage fluid of children with mycoplasma pneumoniae pneumonia(MPP).Methods:A total of 102 children with MPP who were treated in our hospital from January 2020 to March 2022 were selected as the observation group,including 59 children with mild disease and 43 children with severe disease,while 60 children with bronchial foreign bodies were selected as the control group,and the differences in Gal-3,IL-33,MP-DNA load,neutrophils,etc.in alveolar lavage fluid in each group were compared,the changes of Gal-3,IL-33,MP-DNA load and neutrophil in alveolar lavage fluid in the observation group before and after treatment were analyzed.Results:Gal-3,IL-33,MP-DNA load,neutrophils and macrophages in alveolar lavage fluid of the observation group were(18.82±3.10)pg/ml,(20.01±3.43)pg/ml,(5.94±1.01)log copy/ml,(18.21±3.11)%and(88.14±9.92)%,respectively,which were significantly higher than those in the control group(P<0.05).Gal-3,IL-33,MP-DNA load and neutrophil in alveolar lavage fluid of severe children in the observation group were(20.32±3.02)pg/ml,(22.03±3.05)pg/ml,(7.07±1.70)log copy/ml and(20.31±2.88)%respectively,which were significantly higher than those of mild children(P<0.05).Gal-3,IL-33,MP-DNA load,neutrophils and macrophages in alveolar lavage fluid of mild and severe children in the observation group decreased after treatment compared with those before treatment(P<0.05).Gal-3,IL-33,neutrophils in alveolar lavage fluid were positively correlated with MP-DNA load(P<0.05),while no significant correlation was found in the rest.Conclusion:Gal-3,IL-33,MP-DNA load and the proportion of neutrophils in the alveolar lavage fluid of children with MPP are significantly increased,which is related to the severity of the disease,and Gal-3,IL-33,neutrophils in the alveolar lavage fluid are positively related to MP-DNA load.
作者
樊梦洁
杨遥
FAN Mengjie;YANG Yao(Yichang First People's Hospital/People's Hospital of Three Gorges University,Hubei Yichang 443000,China)
出处
《河北医学》
CAS
2023年第6期963-967,共5页
Hebei Medicine
基金
湖北省卫生健康委员会联合基金项目,(编号:WJ2019H513)。
