摘要
目的:探讨血清高迁移率族蛋白B1(HMGB1)、陷窝蛋白-1(Cav-1)水平与股骨骨折髓内钉固定术后延迟愈合的关系。方法:选取2018年1月至2022年7月我院收治的70例股骨骨折髓内钉固定术后延迟愈合患者为延迟愈合组,1∶1配比选取70例股骨骨折髓内钉固定术后正常愈合组患者为正常愈合组。收集患者临床资料,采用ELISA检测血清HMGB1、Cav-1水平。通过多因素Logistic回归分析股骨骨折髓内钉固定术后延迟愈合的影响因素,ROC曲线分析血清HMGB1、Cav-1水平对股骨骨折髓内钉固定术后延迟愈合的预测价值。结果:与正常愈合组比较,延迟愈合组血清HMGB1(2.71±0.42 ng/mL vs 3.68±1.04 ng/mL)、Cav-1(10.85±1.89 ng/mL vs 13.03±2.07 ng/mL)水平降低(t=7.204、6.497,P均<0.001)。多因素Logistic回归分析显示,年龄增加(OR=1.095,95%CI:1.036~1.157)为股骨骨折髓内钉固定术后延迟愈合的独立危险因素,HMGB1(OR=0.936,95%CI:0.904~0.969)、Cav-1(OR=0.599,95%CI:0.470~0.763)升高为独立保护因素(P均<0.05)。ROC曲线分析显示,血清HMGB1、Cav-1水平联合预测股骨骨折髓内钉固定术后延迟愈合的曲线下面积(AUC)大于HMGB1、Cav-1单独预测(Z=2.352、2.621,P均<0.05)。结论:血清HMGB1、Cav-1水平降低与股骨骨折髓内钉固定术后延迟愈合密切相关,可能成为术后延迟愈合的辅助预测指标。
Objective:To investigate the relationship between serum high mobility group protein B1(HMGB1)and caveolin-1(Cav-1)levels and delayed healing after intramedullary nail fixation of femoral fractures.Methods:A total of 70 patients admitted to our hospital from January 2018 to July 2022 with delayed healing after intramedullary nail fixation of femur fractures were selected as the delayed healing group,and 70 patients with normal healing after intramedullary nail fixation of femur fractures were selected in a 1:1 ratio as the normal healing group.Clinical data of the patients were collected and serum HMGB1 and Cav-1 levels were measured by ELISA.The factors influencing delayed healing after intramedullary nail fixation of femoral fractures were analyzed by multi-factor logistic regression,and the ROC curve was used to analyze the predictive value of serum HMGB1 and Cav-1 levels on delayed healing after intramedullary nail fixation of femoral fractures.Results:Serum HMGB1(2.71±0.42 ng/ml vs 3.68±1.04 ng/ml)and Cav-1(10.85±1.89 ng/ml vs 13.03±2.07 ng/ml)levels were reduced in the delayed healing group compared to the normal healing group(t=7.204,6.497,all P<0.001).Multi-factor logistic regression analysis showed that increasing age(OR=1.095,95%CI:1.036 to 1.157)was an independent risk factor for delayed healing after intramedullary nail fixation of femoral fractures,and HMGB1(OR=0.936,95%CI:0.904 to 0.969)and Cav-1(OR=0.599,95%CI:0.470 to 0.763)were elevated as independent protective factors(all P<0.05).ROC curve analysis showed that serum HMGB1,Cav-1 levels combined predicted a greater area under the curve(AUC)for delayed healing after intramedullary nail fixation of femoral fractures than HMGB1,Cav-1 predicted individually(Z=2.352,2.621,all P<0.05).Conclusion:Decreased serum HMGB1 and Cav-1 levels are closely associated with delayed healing after intramedullary nail fixation of femoral fractures and may be an auxiliary predictor of delayed healing after surgery.
作者
赵兴东
林牧
张艳金
邬夏荣
卢懿明
ZHAO Xingdong(Guizhou Aerospace Hospital,Guizhou Zunyi 563000,China)
出处
《河北医学》
CAS
2023年第6期1032-1037,共6页
Hebei Medicine
基金
贵州省卫生健康委科学技术基金项,(编号:gzwjkj2019-2-107)
遵义市科技计划项目(编号:HZ字(2019)222)。
