摘要
目的 探讨中性粒细胞/淋巴细胞比值(NLR)与血小板/淋巴细胞比值(PLR)在自身免疫性脑炎(AE)患者中的临床意义。方法 选取扬州大学附属苏北人民医院2015年1月至2021年10月收治的AE患者53例作为病例组,另选取来该院体检的健康者60例作为对照组。比较病例组和对照组的一般临床资料及2组受试者外周血细胞计数、NLR、PLR,分析NLR、PLR在AE患者中的意义。根据改良Rankin评分量表(mRS),分析NLR与病例组患者预后mRS评分有无相关性。结果 病例组NLR、中性粒细胞、白细胞计数高于对照组,而淋巴细胞、血小板水平低于对照组,差异有统计学意义(P<0.05),而病例组和对照组的PLR比较,差异无统计学意义(P>0.05)。预后良好组(mRS≤1分,n=26)与预后不良组(mRS≥2分,n=8)的NLR比较,差异无统计学意义(P>0.05),病例组的NLR与预后mRS评分无相关性(相关系数=-0.067,P=0.708)。结论 NLR与AE密切相关,对AE有一定的诊断意义。
Objective To investigate the clinical significance of neutrophil to lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)in patients with autoimmune encephalitis(AE).Methods A total of 53 patients from Subei People′s Hospital with autoimmune encephalitis were selected as the case group.A total of 60 healthy people were selected as the control group.The general clinical data and peripheral blood cell count,NLR and PLR levels of the case group and the control group were compared.And the significance of NLR and PLR in AE patients was analyzed.According to the modified Rankin Scale(mRS),the correlation between NLR and the degree of prognosis of patients in the case group was analyzed.Results The NLR,neutrophil and white blood cell count in the case group were higher than those in the control group(P<0.05),while the levels of lymphocyte and blood platelet count of the case group were lower than those in the control group(P<0.05).The PLR between the case group and the control group were not significantly different(P>0.05).The NLR between the good prognosis group(mRS≤1 score,n=26)and the poor prognosis group(mRS≥2 scores,n=8)were not significantly different(P>0.05).The NLR was not correlated with the prognostic mRS score in the case group(r=-0.067,P=0.708).Conclusion NLR is closely related to AE and can be used for the diagnosis of the patients.
作者
苗程
朱艳
刘佩佩
MIAO Cheng;ZHU Yan;LIU Peipei(Medical College of Yangzhou University,Yangzhou,Jiangsu 225001,China;Department of Neurology,Subei People′s Hospital Affiliated to Yangzhou University,Yangzhou,Jiangsu 225001,China)
出处
《现代医药卫生》
2023年第12期2049-2053,共5页
Journal of Modern Medicine & Health
