摘要
目的探讨甲状腺乳头状癌(PTC)合并桥本甲状腺炎(HT)患者在淋巴结转移中白介素-6(IL-6)的表达水平。方法选取上海市徐汇区中心医院2019年11月至2021年10月住院行甲状腺手术患者80例,其中包括PTC合并HT有淋巴结转移患者(A组,40例)、PTC合并HT无淋巴结转移患者(B组,40例)。通过免疫组化方法分别检测比较A、B组患者的性别、年龄、肿瘤大小、包膜有无侵犯、临床分期及正常甲状腺组织、癌旁HT组织、癌组织的IL-6表达水平。结果IL-6在A组和B组的正常甲状腺组织表达阳性率低,均为5.00%;在癌旁HT组织的表达阳性率分别为75.00%、52.50%;在癌组织的表达阳性率分别为95.00%、80.00%。IL-6在癌组织中的表达与患者的性别和年龄无关(P>0.05),与肿瘤大小、淋巴结转移及临床分期有关(P<0.05);A组与B组比较,IL-6在癌旁HT组织及癌组织中的表达水平有统计学意义(P<0.05)。结论IL-6在PTC合并HT患者中表达,且淋巴结阳性患者的表达水平明显增高,其可能促进了淋巴结的转移;IL-6与肿瘤的大小及包膜侵犯相关;提示其与HT及PTC的发生、发展有关。
Objective To investigate the expression level of interleukin-6(IL-6)in lymph node metastasis in patients with papillary thyroid carcinoma(PTC)complicated with Hashimoto thyroiditis(HT).Methods A total of 80 patients who underwent thyroid surgery in Shanghai Xuhui Central Hospital from November 2019 to October 2021 were selected,and they were divided into group A(PTC complicated with HT with lymph node metastasis,n=40)and group B(PTC complicated with HT without lymph node metastasis,n=40).Immunohistochemical method was used to detect and compare the gender,age,tumor size,capsular invasion,clinical stage and IL-6 expression level in normal thyroid tissues,HT tissues adjacent to cancer and tumor tissues.Results The positive rates of IL-6 expression in normal tissues of group A and group B were low,both of which were 5.00%.The positive rates of IL-6 expression in HT tissues adjacent to cancer were 75.00%and 52.50%,respectively.The positive rates of IL-6 expression in cancer tissues were 95.00%and 80.00%,respectively.The expression of IL-6 in cancer tissues was not correlated to the gender and age of patients(P>0.05),but is correlated to tumor size,lymph node metastasis and clinical stage(P<0.05).There were statistically significant differences between group A and group B in the expression levels of IL-6 in HT issues adjacent to cancer and cancer tissues(P<0.05).Conclusion IL-6 is expressed in patients with PTC complicated with HT,and the expression level of lymph node positive patients is obviously increased,which may promote lymph node metastasis.IL-6 is correlated to tumor size and capsular invasion,suggesting that it is related to the occurrence and progression of HT and PTC.
作者
褚茜茜
王晖
马世红
王小龙
艾志龙
CHU Qianqian;WANG Hui;MA Shihong;WANG Xiaolong;AI Zhilong(Department of General Surgery,Shanghai Xuhui Central Hospital,Shanghai 200031,China;Department of General Surgery,Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China)
出处
《中国医药科学》
2023年第11期172-175,共4页
China Medicine And Pharmacy
基金
上海市徐汇区医学科研项目(SHXH202031)
上海市徐汇区中心医院引进人才项目(007)
上海市徐汇区中心医院科研课题(2018XHYY-10)。
