摘要
目的:分析甘油三酯/胱抑素C比值(TG/CysC)预测妊娠期高血压疾病(HDCP)患者早期肾功能损伤价值。方法:回顾性收集2019年5月-2022年5月本院产前检查确诊为HDCP孕妇98例为HDCP组,正常孕妇90例为对照组。均检测血清中TG、CysC水平并计算TG/CysC比值。根据HDCP组随访是否发生早期肾功能损伤分为肾功能正常组(n=60)与肾功能损伤组(n=38),比较各组血清TG、CysC水平及TG/CysC比值,采用受试者工作特征曲线(ROC)评估TG/CysC比值预测HDCP患者早期肾功能损伤价值。结果:HDCP组TG/CysC比值(2.13±0.28)低于对照组(3.57±0.47),且肾功能损伤组TG/CysC比值(1.76±0.22)低于肾功能正常组(2.63±0.44)(均P<0.05)。ROC曲线分析,TG/CysC比值预测HDCP患者早期肾功能损伤的曲线下面积为0.921,截断值为2.14,灵敏度86.3%、特异性85.2%,阳性预测值86.7%、阴性预测值85.6%。结论:HDCP患者外周血TG/CysC比值降低,且早期肾功能损伤患者更低,可作为预测HDCP患者发生早期肾功能损伤的有效临床指标。
Objective:To explore the value of the ratio of triglyceride to cystatin C(TG/CysC)of pregnant women with hypertensive disorders complicating pregnancy(HDCP)for predicting their early renal impairment.Methods:A total of 98pregnant women with HDCP confirmed during antenatal examination from May 2019to May 2022were collected in study group retrospectively,and 90normal pregnant women who came to hospital for prenatal examination were selected in control group during the same period.The levels of serum TG and CysC of the women in the two groups were detected,and the ratio of TG/CysC of the women was calculated.The women in the study group were divided into group A(60women with normal renal function)and group B(38women with renal function impairment)according to whether early renal function impairment occurred or not during the follow up.The levels of serum TG and CysC,and the ratio of TG/CysC of the women were compared among these groups.Receiver operating characteristic curve(ROC)was used to evaluate the value of the ratio of TG/CysC of the women with HDCP for predicting their early renal impairment.Results:The ratio of TG/CysC(2.13±0.28)of the women in the study group was significantly lower than that(3.57±0.47)of the women in the control group,and which(1.76±0.22)of the women in group B was significantly lower than that(2.63±0.44)of the women in group A(all P<0.05).ROC curve analysis showed that the area under the curve,the cutoff value,the sensitivity,the specificity,the positive predictive value,and the negative predictive value of the ratio of TG/CysC of the women with HDCP for predicting their early renal function impairment were 0.921,2.14,86.3%,85.2%,86.7%,and 85.6%,respectively.Conclusion:The ratio of TG/CysC in peripheral blood of the pregnant women with HDCP decreases,and which of the women with early renal function impairment more decreases.So it can be used as the clinical indicator for predicting the early renal function impairment of with HDCP.
作者
黄霞
丁莉
崔晶娴
HUANG Xia;DING Li;CUI Jinxian(Haian People's Hospital,Haian,Jiangsu Province,226600;Affiliated Hospital of Yangzhou University,Yangzhou,Jiangsu Province)
出处
《中国计划生育学杂志》
2023年第6期1408-1411,共4页
Chinese Journal of Family Planning
关键词
妊娠期高血压
肾功能损伤
甘油三酯/胱抑素C比值
预测
Hypertensive disorders complicating pregnancy
Renal impairment
Ratio of Triglyceride to cystatin C
Prediction
