摘要
目的探讨血清淀粉样蛋白A(SAA)、超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)对儿童过敏性紫癜(HSP)的联合诊断价值。方法选取2018年9月至2022年10月于安徽医科大学附属巢湖医院儿科确诊为HSP患儿98例作为观察组,并选取同期健康儿童98名作为对照组,比较两组患儿的一般资料以及SAA、hs-CRP、IL-6水平,并通过多因素Logistic回归分析HSP的独立影响因素,采用受试者工作特征曲线(ROC)分析SAA、hs-CRP、IL-6单独以及联合检测对HSP的诊断价值。结果观察组患儿的SAA、hs-CRP、IL-6水平均明显高于对照组,差异具有统计学意义(t=31.566、29.430、26.857,P<0.05)。单因素分析结果显示,Hp感染、药物过敏史、家族史与HSP发生有关(χ^(2)=27.000、11.696、5.548,P<0.05)。多因素Logistic回归分析结果显示,血清SAA、hs-CRP、IL-6、HP感染为HSP的独立危险因素(P<0.05)。ROC曲线结果显示,SAA、hs-CRP、IL-6单独检测以及联合检测诊断HSP的曲线下面积(AUC)为0.894、0.701、0.769、0.920。结论SAA、hs-CRP、IL-6联合检测对儿童HSP具有较高的诊断价值,值得临床进行推广。
Objective To investigate the combined diagnostic value of serum amyloid A(SAA),high⁃sensitivity C⁃reactive protein(hs CRP)and interleukin⁃6(IL⁃6)in children with henoch schonlein purpura(HSP).Methods From September 2018 to October 2022,98 children diagnosed as HSP in the Department of Pe⁃diatrics of Chaohu Hospital Affiliated to Anhui Medical University were selected as the observation group,and 98 healthy children in the same period were selected as the control group.The general data,SAA,hs CRP,and IL⁃6 levels between the two groups of children were compared,and the independent influencing factors of HSP were analyzed by multivariate logistic regression.The diagnostic value of SAA,hs CRP,and IL⁃6 alone and in combi⁃nation for HSP was analyzed using the receiver operating characteristic curve(ROC).Results The levels of SAA,hs CRP and IL⁃6 in the observation group were significantly higher than those in the control group(t=31.566,29.430,26.857,P<0.05).Univariate analysis showed that Hp infection,drug allergy history and family history were related to the occurrence of HSP(χ^(2)=27.000,11.696,5.548,P<0.05).Multivariate logistic regres⁃sion analysis showed that serum SAA,hs CRP,IL⁃6 and HP infection were independent risk factors for HSP(P<0.05).The ROC curve results showed that the area under the curve(AUC)of SAA,hs CRP,IL⁃6 detection alone and in combination for diagnosing HSP were 0.894,0.701,0.769,0.920.Conclusion The combined detection of SAA,hs CRP and IL⁃6 has a high diagnostic value for children with HSP and is worthy of clinical promotion.
作者
周春荣
张宝辉
任磊
ZHOU Chunrong;ZHANG Baohui;REN Lei(Department of Pediatrics,Chaohu Hospital Affiliated to Anhui Medical University,Chaohu,Anhui,China,238000)
出处
《分子诊断与治疗杂志》
2023年第5期768-771,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽省公益性研究联动计划项目(15011d04060)。
