摘要
目的 探讨大剂量雌激素联合低分子肝素对宫腔镜下宫腔粘连分离术(TCRA)后再妊娠患者子宫内膜容受性的影响。方法 选取2018年1月—2020年12月在嘉兴市中医医院就诊的152例TCRA后再妊娠患者为研究对象,按照随机数字表法分为肝素组(76例)和激素联合组(76例)。激素联合组采用大剂量雌激素联合低分子肝素治疗,肝素组给予低分子肝素治疗;采用化学发光法检测性激素黄体生成素(LH)、促卵泡成熟素(FSH)及雌二醇(E_(2))水平;采用B超检测患者子宫内膜厚度、子宫内膜容积;统计两组患者治疗后临床疗效、妊娠病理发生情况及不良反应。结果 与肝素组比较,激素联合组内膜容积显著升高,差异有统计学意义(P<0.05)。与肝素组比较,激素联合组内膜厚度及FSH、LH及E_(2)水平显著降低,差异均有统计学意义(均P<0.05)。与肝素组比较,激素联合组治疗总有效率较高,差异有统计学意义(χ^(2)=4.802,P<0.05)。结论 使用大剂量雌激素联合低分子肝素治疗可显著治愈并改善TCRA后再妊娠患者子宫内膜容受性及临床症状,促进患者身体恢复,效果较为理想。
ObjectiveEffects of high dose estrogen combined with low molecular weight heparin on endometrial receptivity after hys-teroscopic intrauterine adhesion separation(TCRA)were studied.Methods From January 2018 to December 2020,152 TCRA patients treated in our hospital were selected as study object,According to the random number table,76 cases were divided into heparin group,There were 76 cases in hormone group.Hormone group was treated with high dose estrogen and low molecular weight heparin,Heparin group was treated with low molecular weight heparin;The levels of sex hormones progesterone(LH),follicle-stimulating hormone(FSH)and es-tradiol(E,)were detected by chemiluminescence;Endometrial thickness and endometrial volume were measured by B ultrasound;The clini-cal effect,pathological occurrence and adverse reactions of pregnancy after treatment in the two groups were analyzed.Results Compared with heparin group,intimal volume increased significantly in hormone combined group(P<0.05).Compared with heparin group,intimal thickness and FSH、LH and E,level in hormone group decreased significantly(P<0.05).Compared with heparin group,the total effective rate of hormone combined group was higher(x2=4.802,P<0.05).Conclusion High dose estrogen combined with low molecular weight heparin can significantly cure and improve endometrial receptivity and clinical'symptoms in patients with pregnancy after TCRA,and promote the recovery of patients.
作者
贺俊霞
杨晓敏
马瑞芬
HE Jun-xia;YANG Xiao-min;MA Rui-fen(Department of gynaecology,Jiaxing Hospital of traditional Chinese Medicine,Jiaxing,Zhejiang 314000,China)
出处
《中国妇幼保健》
CAS
2023年第12期2210-2213,共4页
Maternal and Child Health Care of China
基金
浙江省嘉兴市科技局公益性研究计划项目(2018AD32139)。
关键词
大剂量雌激素
低分子肝素
再妊娠
宫腔镜下宫腔粘连分离术
子宫内膜容受性
High-dose estrogen
Low-molecular-weight heparin
Hysteroscopic intrauterine adhesions separation
Re-pregnancy
Endometrial receptivity
