摘要
目的研究阿霉素联合脉冲射频治疗顽固性三叉神经痛的临床疗效及其安全性。方法选取2017年8月—2019年7月南充市中心医院收治的顽固性三叉神经痛患者90例作为研究对象,采用随机数表法将其分为参照组(提供半月神经节脉冲射频治疗)和观察组(半月神经节脉冲射频加阿霉素注射治疗),各45例。对比两组患者治疗总有效率、VAS疼痛评分、不良反应率以及复发率。结果观察组治疗总有效率(97.78%)高于参照组(84.44%),差异有统计学意义(χ^(2)=4.939,P=0.026)。术后7d、30d、半年、1年的VAS评分[(1.02±0.23)分vs(3.54±0.41)分]、[(1.25±0.23)分vs(3.54±0.54)分]、[(1.47±0.34)分vs(3.43±0.20)分]、[(1.17±0.23)分vs(3.41±0.25)分],观察组明显低于参照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。术后随访3年,观察组复发率(2.22%)低于参照组(17.78%),差异有统计学意义(P<0.05)。结论阿霉素联合脉冲射频治疗顽固性三叉神经痛的临床疗效显著,有利于降低疾病复发率。
Objective Study on the clinical efficacy and safety of doxorubicin combined with pulse radiofrequency therapy for refractory trigeminal neuralgia.Methods A total of 90 patients with intractable trigeminal neuralgia admitted to Nanchong Central Hospital from August 2017 to July 2019 were selected as the study subjects.Random number method was used to divide them into reference group(provide semilunar ganglion pulsed radiofrequency treatment)and observation group(penislunar ganglion pulsed radiofrequency plus doxorubicin injection treatment),with 45 cases in each group.The total effective rate,VAS pain score,adverse reaction rate and recurrence rate were compared between the two groups.Results The total effective rate of the observation group(97.78%)was higher than that of the reference group(84.44%),the difference was statistically significant(χ^(2)=4.939,P=0.026).The VAS scores[(1.02±0.23)points vs(3.54±0.41)points],[(1.25±0.23)points vs(3.54±0.54)points],[(1.47±0.34)points vs(3.43±0.20)points],[(1.17±0.23)points vs(3.41±0.25)points]at 7 d,30 d,half a year,and 1 year after surgery were significantly lower in the observation group than in the reference group,the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups of patients(P>0.05).After a 3-year follow-up,the recurrence rate in the observation group(2.22%)was lower than that in the reference group(17.78%),the difference was statistically significant(P<0.05).Conclusion Doxorubicin combined with pulsed radiofrequency has a significant clinical effect in the treatment of intractable trigeminal neuralgia,which is beneficial to reduce the recurrence rate of the disease.
作者
杨颖
YANG Ying(Department of Pain,Nanchong Central Hospital,Nanchong,Sichuan Province,637000 China)
出处
《世界复合医学》
2023年第3期181-183,198,共4页
World Journal of Complex Medicine
基金
四川省中医药管理局科学技术研究专项课题(2021MS352)。
关键词
顽固性三叉神经痛
阿霉素
VAS评分
不良反应率
复发率
Intractable trigeminal neuralgia
Doxorubicin
VAS score
Adverse reaction rate
Recurrence rate
