摘要
目的:基于Meta分析方法评估药泥灸治疗膝骨关节炎(Knee Osteoarthritis,KOA)的临床疗效。方法:检索PubMed、Cochrane Library等数据库中从建库至2022年10月22日关于药泥灸治疗KOA的所有随机对照试验文献,将检索到的文献使用EndNote X9.1软件、Cochrane偏倚风险评估工具、RevMan 5.4软件进行筛选、质量评估和Meta分析。结果:最终纳入文献12篇,涉及患者862例。Meta分析结果显示:试验组(接受单纯药泥灸或药泥灸联合口服中西药、针灸等疗法)的临床有效率高于对照组。在西安大略和麦克马斯特大学骨关节炎指数(Osteoarthritis Index of Western Ontario and McMaster University,WOMAC)评分、疼痛视觉模拟评分法(Visual Analogue Scale,VAS)评分方面,试验组均优于对照组。12项研究中有3项出现轻度不良反应。结论:单纯药泥灸或药泥灸联合其他中西医常规疗法治疗KOA有一定的临床疗效,安全性尚可,并可改善WOMAC评分、疼痛VAS评分等评价指标。本研究纳入研究较少且质量较低,期待后续更多高质量研究对上述结论进行验证。
Objective:To conduct a Meta-analysis of the clinical efficacy of medicinal mud moxibustion in the treatment of knee osteoarthritis.Methods:Databases such as PubMed and Cochrane Library were searched to select all the randomized controlled trials of treating knee osteoarthritis by medicinal mud moxibustion from the establishment of each database to October 22,2022.The retrieved literature was screened,quality evaluated and Meta-analyzed by EndNote X9.1 software,Cochrane bias risk assessment tool and RevMan 5.4 software.Results:A total of 12 studies with 862 cases were included finally.The results of the Meta-analysis showed that the test group was better than the control group in improving the clinical efficacy.After treatment,the test group was better than the control group in WOMAC score and VAS score.Mild adverse reactions occurred in 3 of the 12 studies.Conclusion:Whether it is simply medicinal mud moxibustion,or medicinal mud moxibustion plus other TCM or Western medicine conventional therapy,it shows a certain clinical effect on KOA,with acceptable safety.The above two therapies can also ameliorate WOMAC score,VAS score and other evaluation indicators.However,since there are few studies included in and the quality is low,more high-quality studies are expected to verify the above conclusions in the future.
出处
《中医临床研究》
2023年第10期91-99,共9页
Clinical Journal Of Chinese Medicine
基金
山西省重大科技攻关专项:雷火灸智能机器人的研发与应用(2021XM05)。
关键词
药泥灸
膝骨关节炎
临床疗效
随机对照试验
META分析
Medicinal mud moxibustion
Knee osteoarthritis
Clinical efficacy
Randomized controlled trial
Meta-analysis
