摘要
肠道微生物群与宿主是共生关系,二者共同进化。短链脂肪酸(short-chain fatty acids,SCFAs)通过保护肠上皮屏障的完整性来维持肠道内环境平衡,并通过影响肠道免疫细胞的分化调节免疫系统。作为肠道微生物群发酵膳食纤维产生的一类重要代谢物,SCFAs通过抑制组蛋白脱乙酰酶或激活G蛋白偶联受体调节肠道免疫细胞功能与分化,在宿主的健康和免疫介导的疾病中发挥至关重要的作用。该文从SCFAs的来源、运输和信号转导,以及SCFAs对免疫细胞、免疫屏障及肠道疾病的影响等六个方面展开综述,并重点介绍了SCFAs对免疫细胞的作用。
Gut microbiota co-evolve with host symbiotic relationships.Short-chain fatty acids(SCFAs)maintain intestinal homeostasis by protecting the integrity of the intestinal epithelial barrier,and regulate the function of innate immune cells involved in the immune system.As a class of important metabolites produced by the fermentation of dietary fiber in the gut microbiota,SCFAs regulate the function and differentiation of intestinal immune cells by inhibiting histone deacetylases or activating G-protein-coupled receptors,playing a vital role in disease.This article reviews the production of SCFAs,transport and signal transduction,and the effects of SCFAs on immune cells,immune barriers and intestinal diseases,and focuses on the effects of SCFAs on immune cells.
作者
崇洁
马继登
张进威
孙静
CHONG Jie;MA Ji-Deng;ZHANG Jin-Wei;SUN Jing(Chongqing Academy of Animal Sciences,Chongqing 402460,China;Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province,Sichuan Agricultural University,Chengdu 611130,China;National Pig Technology Innovation Center,Chongqing 402460,China;Key Laboratory of Pig Industry Science,Ministry of Agriculture,Chongqing 402460,China;Chongqing Engineering Technology Research Center for the Development and Utilization of Medical Animal Resources,Chongqing 402460,China)
出处
《生命科学》
CSCD
北大核心
2023年第5期663-670,共8页
Chinese Bulletin of Life Sciences
基金
重庆市自然科学基金项目(cstc2021jcyjmsxmX0630
21509)
国家生猪技术创新中心先导科技项目(22613)
国家生猪技术创新中心奖补项目(21608)。
