摘要
目的:探讨甲苯磺酸瑞马唑仑用于全身麻醉患者中的临床效果。方法:选取2020年8月—2022年8月东营市东营区中心医院麻醉科收治的80例全身麻醉患者,采用随机数字表法划分为对照组与观察组各40例。对照组麻醉诱导应用丙泊酚,观察组麻醉诱导应用甲苯磺酸瑞马唑仑。比较两组不同时段的血流动力学指标、脑电双频指数(BIS)、不良反应发生率、麻醉及苏醒情况。结果:观察组患者T_(1)~T_(4)时刻的平均动脉压(MAP)、心率、BIS值均高于对照组,差异有统计学意义(P<0.05),观察组各时刻MAP、心率变化波动小,两组各时刻的SpO_(2)值比较,差异无统计学意义(P>0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组镇静诱导时间短于对照组,差异有统计学意义(P<0.05),两组患者意识恢复时间、拔除喉罩时间、PACU停留时间比较,差异无统计学意义(P>0.05)。结论:在全身麻醉中应用甲苯磺酸瑞马唑仑,可更好地保障麻醉诱导及维持的有效性及安全性,稳定血流动力学,控制不良反应发生。
Objective To explore the clinical effect of remimazolam tosilate in patients under general anesthesia.Methods A total of 80 patients with general anesthesia admitted to Dongying Central Hospital from August 2020 to August 2022 were selected as the research objects,and were divided into control group(anesthetic induction with propofol)and observation group(anesthetic induction with remimazolam tosilate)by random number table method,with 40 cases in each group.Hemodynamic indexes,bispectral index(BIS),incidence of adverse reactions,anesthesia and recovery were compared between the two groups at different time periods.Results The mean arterial pressure(MAP),heart rate and BIS values of patients in the observation group were higher than those in the control group at the same time(P<0.05),but the changes of MAP and heart rate in the observation group fluctuated little at each time,and there was no statistical difference in SpO_(2) values between the two groups at each time(P>0.05).The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05).Compared with the control group,the induction time of sedation in the observation group was shorter(P<0.05).The recovery time of consciousness,the time of removing laryngeal mask and the stay time in the postanesthesia care unit(PACU)were compared between the two groups,and there were no statistical difference(P>0.05).Conclusion The application of remimazolam tosilate in general anesthesia can better ensure the effectiveness and safety of anesthesia induction and maintenance,stabilize hemodynamics and control the occurrence of adverse reactions.
作者
孙广海
尹燕
SUN Gunghai;YIN Yan(Department of Anesthesiology,Dongying Central Hospital,Dongying,Shandong 257097,China)
出处
《医药前沿》
2023年第10期10-12,共3页
Journal of Frontiers of Medicine
