摘要
目的探讨泮托拉唑四联疗法对幽门螺杆菌(Hp)阳性胃溃疡患者Hp根除率和炎性因子水平的影响。方法抽取2020年6月至2022年10月登封三康医院收入的Hp阳性胃溃疡患者82例,依据数字表法分为对照组与观察组,各41例,对照组接受奥美拉唑四联疗法治疗,观察组接受泮托拉唑四联疗法治疗,就两组患者治疗效果、Hp根除率、炎症指标、胃黏膜愈合情况及不良反应进行组间比较。结果观察组患者治疗有效率、Hp根治率均高于对照组,且观察组患者治疗后各项炎症指标、各项胃黏膜愈合评分均低于对照组,差异有统计学意义(P<0.05);两组患者不良反应发生率相比,差异无统计学意义(P>0.05)。结论对于Hp阳性胃溃疡患者开展泮托拉唑四联疗法治疗相较于奥美拉唑四联疗法治疗具有积极意义,可有效提升治疗效果与Hp根治率,降低炎症指标,改善胃黏膜愈合状况,且安全性较高。
Objective To explore the effect of pantoprazole tetraplex therapy on Hp eradication rate and levels of inflammatory factors in patients with Helicobacter pylori(Hp)positive gastric ulcers.Methods A total of 82 positive Hp patients with gastric ulcer treated from June 2020 to October 2022 in Dengfeng Sankang Hospital were selected.According to random number table,patients were assigned to control group(n=41,omeprazole quadruple therapy)and observation group(n=41,pantoprazole quadruple therapy).Treatment effect,Hp clearance rates,inflammatory factors,gastric mucosa healing conditions and adverse drug reactions were evaluated between two groups.Results The total effective rate and Hp clearance rate in the observation group were higher than those in the control group;The inflammatory factors and gastric mucosa healing scores in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);The adverse drug rate between groups was not significantly different(P>0.05).Conclusion Compared with omeprazole quadruple therapy,pantoprazole quadruple therapy has a positive significance for patients with Hp positive gastric ulcer,which can effectively improve the treatment effect and Hp radical rate,reduce inflammatory indicators,improve the healing of gastric mucosa,and has high safety.
作者
范洪伟
FAN Hongwei(Department of Gastroenterology,Dengfeng Sankang Hospital,Dengfeng Henan 452470,China)
出处
《临床研究》
2023年第7期38-40,共3页
Clinical Research
关键词
泮托拉唑
四联疗法
胃溃疡
幽门螺旋杆菌
炎症指标
pantoprazole
quadruple therapy
gastric ulcer
helicobacter pylori
inflammatory factors
