摘要
目的分析气滞血瘀型原发性痛经患者应用膈下逐瘀汤加减治疗的疗效。方法70例气滞血瘀型原发性痛经患者,通过简单随机分组法分为对照组与观察组,各35例。对照组患者实施常规西医治疗,观察组患者实施膈下逐瘀汤加减治疗。比较两组患者临床疗效,治疗前后中医证候积分、月经期疼痛评分、前列腺代谢指标[前列腺素F2α(PGF_(2α))、前列腺素E2(PGE_(2))]水平。结果观察组临床总有效率为94.29%,明显高于对照组的74.29%,差异具有统计学意义(P<0.05)。治疗前,两组患者的中医证候积分、月经期疼痛评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的中医证候积分、月经期疼痛评分均低于本组治疗前,观察组患者的中医证候积分(1.03±0.05)分、月经期疼痛评分(1.92±0.37)分均低于对照组的(2.94±0.21)、(3.01±0.54)分,差异具有统计学意义(P<0.05)。治疗前,两组患者的PGF_(2α)、PGE_(2)水平比较,差异无统计学意义(P>0.05);治疗后,两组患者的PGF_(2α)水平均低于治疗前,PGE_(2)水平均高于治疗前,观察组患者的PGF_(2α)(29.67±2.83)ng/L低于对照组的(38.92±3.49)ng/L,PGE_(2)(30.85±2.02)ng/L高于对照组的(25.79±1.16)ng/L,差异具有统计学意义(P<0.05)。结论膈下逐瘀汤加减应用于气滞血瘀型原发性痛经患者的临床治疗中,可获得理想疗效,促进患者病症改善,缓解患者的机体不适感。
Objective To analyze the efficacy of modified Gexia Zhuyu Decoction in the treatment of primary dysmenorrhea with Qi stagnation and blood stasis syndrome.Methods A total of 70 cases of primary dysmenorrhea with Qi stagnation and blood stasis syndrome were divided into control group and observation group by simple random grouping,with 35 cases in each group.The control group was treated with conventional Western medicine,and the observation group was treated with modified Gexia Zhuyu Decoction.Both groups were compared in terms of clinical efficacy,traditional Chinese medicine syndrome score,menstrual pain score and the levels of prostate metabolic indexes[prostaglandin F2α(PGF2_(α)),prostaglandin E2(PGE_(2))]before and after treatment.Results The total clinical effective rate of the observation group was 94.29%,which was significantly higher than that of 74.29%of the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in traditional Chinese medicine syndrome score and menstrual pain score between the two groups(P>0.05).After treatment,the traditional Chinese medicine syndrome score and menstrual pain score in the two groups were lower than those before treatment in this group;traditional Chinese medicine syndrome score of(1.03±0.05)points and menstrual pain score of(1.92±0.37)points in the observation group were lower than those of(2.94±0.21)and(3.01±0.54)points in the control group;the differences were statistically significant(P<0.05).Before treatment,there was no statisticaally significant difference in PGF2_(α)and PGE_(2) levels between the two groups(P>0.05).After treatment,PGF2_(α)level in the two groups was lower than that before treatment in this group,and PGE_(2) level was higher than that before treatment in this group;PGF2_(α)of(29.67±2.83)ng/L in the observation group was lower than that of(38.92±3.49)ng/L in the control group;PGE_(2) of(30.85±2.02)ng/L in the observation group was higher than that of(25.79±1.16)ng/L in the control group;the differences were statistically significant(P<0.05).Conclusion In the treatment of primary dysmenorrhea with Qi stagnation and blood stasis syndrome,modified Gexia Zhuyu Decoction can obtain ideal efficacy,promote the improvement of patients'symptoms,and relieve patients'body discomfort.
作者
郭艳苓
GUO Yan-ling(Tengzhou Hospital of Traditional Chinese Medicine,Tengzhou 277599,China)
出处
《中国实用医药》
2023年第11期137-140,共4页
China Practical Medicine
关键词
气滞血瘀型
原发性痛经
膈下逐瘀汤加减
中医证候积分
Qi stagnation and blood stasis syndrome
Primary dysmenorrhea
Modified Gexia Zhuyu Decoction
Traditional Chinese medicine syndrome score
