摘要
采用气相色谱法,检测化学原料药安乃近残留溶剂甲醇的含量。检测方法为采用Agilent DB-WAX柱,FID检测器,检测器温度为230℃,进样器温度为200℃,柱温为55℃,以DMF作为溶剂,氮气为载气,在程序升温条件下进行检测,以外标法进行计算。结果表明,甲醇浓度在0.7424~721μg/m L具有良好的线性关系,相关系数R^(2)=0.9998,线性方程Y=171.24 x+172.72,相对误差RSD<5%,该检测方法得到的峰型较好,溶剂峰和甲醇峰分离度好,且操作简单,快速,准确,灵敏度高,可定量检测甲醇含量,为提高安乃近产品的质量提供了保障。
Gas chromatography was used to detect the content of chemical drug.The detection method is as follows:using Agilent DB-WAX column,FID detector,detector temperature 230℃,sampler temperature 200℃,column temperature 55℃,DMF as solvent,nitrogen as carrier gas,tested under the program heating condition,and calculated by external standard method.The results show that the methanol concentration has a good linear relationship between 0.7424 u g/mL and 721 u g/ml,the correlation coefficient R^(2)=0.9998,linear equationY=171.24 x+172.72,relative error RSD less than 5%,the detection method obtained good peak type,good solvent peak and methanol peak separation,and simple operation,fast,accurate,high sensitivity,quantitative detection of methanol content,to improve the quality of the products.
作者
张晓灿
康倩
李焕君
王莉莉
王丽
马凤霞
刘晓莲
马宁宁
Zhang Xiaocan;Kang Qian;Li Huanjun;Wang Lili;Wang Li;Ma Fengxia;Liu Xiaolian;Ma Ningning(Hebei Jiheng Pharmaceutical Corporation Ltd.,Hengshui 053000,China)
出处
《煤炭与化工》
CAS
2023年第5期133-137,共5页
Coal and Chemical Industry
关键词
安乃近
甲醇
残留溶剂
气相色谱法
程序升温
外标法
analgin
methanol
residual solvent
gas chromatography
procedural heating
external standard method
