摘要
近视严重危害儿童青少年视力健康,其发病率逐年上升,已经成为世界性的公共卫生问题。骨形成蛋白(BMP)是一种多功能生长因子,属于转化生长因子-β(TGF-β)中的一员,在动物和人眼组织中广泛表达,与近视发生发展密切相关。因此,本文主要阐述BMP信号通路分子机制及其在近视发病机制中作用的研究进展。
Myopia poses a great threat to the visual function of children and teenagers.As its prevalence increases year by year,it has become a global public health concern.Bone morphogenetic proteins(BMP)are multi-functional growth factors belonging to the transforming growth factor-beta superfamily and are widely expressed in the ocular tissues of humans and animals.Thus,BMP are closely related to the occurrence and development of myopia.This article reviews the molecular mechanism of the BMP signaling pathway and the recent advance in its role in the pathogenesis of myopia.
作者
叶天宇
郝琪
毕宏生
吴秋欣
YE Tianyu;HAO Qi;BI Hongsheng;WU Qiuxin(Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong Province,China;Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine,Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases,Institute of Ophthalmology Disease Prevention and Control of Shandong,Jinan 250002,Shandong Province,China)
出处
《眼科新进展》
CAS
北大核心
2023年第7期575-579,共5页
Recent Advances in Ophthalmology
基金
国家自然科学基金项目(编号:82104937)
山东省医药卫生科技发展计划项目(编号:2019WS571,202007020896)。
关键词
骨形成蛋白
信号通路
近视
bone morphogenetic proteins
signaling pathway
myopia
