摘要
目的:基于数据挖掘探讨含钩藤方剂的配伍及组方规律,为钩藤的规范科学使用提供依据。方法:收集含有钩藤的相关中药方剂,并统计方剂涉及中药的使用频次、性味归经等基本信息。借助VOSviewer 1.6.15软件展示含钩藤方剂的中药配伍密度;基于Apriori算法、利用IBM SPSS Modeler 18.0软件挖掘中药间配伍组合,并绘制关联规则网络。结果:共纳入方剂313首,涉及中药330味。与钩藤配伍的中药以平肝息风药、清热药、解表药为主,临床上主要治疗眩晕、惊风、癫痫等疾病。配伍密度及关联分析显示常与钩藤配伍的中药有甘草、天麻、朱砂、僵蚕、牛黄等。结论:钩藤常与平肝息风类、清热类、解表类中药配伍应用,发挥清热平肝、息风止痉等功效,临床多用于治疗眩晕、惊风、癫痫等疾病。
Objective:To explore the compatibility and regular pattern of the prescriptions containing Uncariae Ramulus Cum Uncis based on data mining,to provide a basis for the standardized and scientific usage of Uncariae Ramulus Cum Uncis.Methods:The related prescriptions of Uncariae Ramulus Cum Uncis,and the basic information of the frequency of use,nature,taste and meridian tropism of traditional Chinese medicines involved in the prescriptions were collected.The compatibility density of traditional Chinese medicine of prescriptions containing Uncariae Ramulus Cum Uncis was demonstrated with the help of VOSviewer 1.6.15 software;Based on the Apriori algorithm,IBM SPSS Modeler 18.0 software was used to mine the compatibility combinations among traditional Chinese medicine,and the association rule network was drawn.Results:A total of 313 prescriptions were included,involving 330 traditional Chinese medicines.The traditional Chinese medicines compatible with Uncariae Ramulus Cum Uncis were mainly composed of drugs for calming liver to stop endogenous wind,antipyretic drugs,and drugs for relieving exterior syndrome,which were mainly used in the treatment of vertigo,convulsion,epilepsy and other diseases.Compatibility density and correlation analysis demonstrated that there were Glycyrrhizae Radix et Rhizoma,Gastrodiae Rhizoma,Cinnabaris,Bombyx Batryticatus,Bovis Calculus that were commonly compatible with Uncariae Ramulus Cum Uncis.Conclusion:Uncariae Ramulus Cum Uncis is often compatible with drugs for calming liver to stop endogenous wind,antipyretic drugs,and drugs for relieving exterior syndrome to exert the effects of clearing heat and calming liver,relieving wind and relieving spasm,and is often used in the treatment of vertigo,convulsion,epilepsy and other diseases in clinic.
作者
王生
丁韩梦
WANG Sheng;DING Han-meng(Nanyang Zhang Zhongjing Hospital,Nanyang 473000,China;Nanyang Medical College,Nanyang 473004,China)
出处
《中国合理用药探索》
CAS
2023年第6期128-134,共7页
Chinese Journal of Rational Drug Use
基金
河南省中医药科学专项(20-21ZY3033)。
关键词
钩藤
数据挖掘
组方规律
关联规则
配伍密度
Uncariae Ramulus Cum Uncis
data mining
regular pattern of the prescriptions
association rules
compatibility density
