摘要
安全、有效和可控是药品基本属性,量-时-效关系的阐明为关键科学和技术问题,长期制约中药复方作用模式的解析和药物创制。单成分的药效动力学(pharmacodynamics,PD)与药动学(pharmacokinetics,PK)呈相关性,可用PK的量-时关系代替PD的效-时关系,而中药复方谱动学(polypharmacokinetics,PPK)参数能否代替谱效动力学(polypharmacodynamics,PPD)参数成为研究的难点。通过生物超分子体按“印迹模板”产生“气析”药效和量-时-效定量函数怎样实现可积分的视角,分析中药PPK与PPD研究方法的不足,探讨中药多成分与单成分在量-时-效关系研究方法学上的差异,阐明PK/PD模型仅适用单成分量-时-效关系表达,而中药的PPK/PPD模型必须单独创立的客观必然性,提出中药PPK与PPD关联的成分簇按“印迹模板”整合简化和对不可积分项用幂级数展开积分的关键问题解决对策,为中药复杂体系解析模式研究提供理论依据。
Safety,effectiveness and controllability are the basic attributes of drugs,and the elucidation of dosage-time-effect relationship is a key scientific and technical issue,which has restricted the mechanism analysis of function of the traditional Chinese medicine(TCM)and the creation of new drugs for long time.The pharmacodynamics(PD)of single component is correlated with pharmacokinetics(PK),and the time-effect relationship of PD can be presented by the time-quantity relationship of PK.Therefore,whether and how to use the polypharmacokinetic parameters of the CMM compounds to present the polypharmacodynamic parameters has become a matter of great concern to the researchers.In this paper,based on the evolution process of the TCM and human body in nature,from the perspective of how biological supermolecules carrying out“Qi chromatography”efficacy and how the quantitative function of dosage-time-effect can be integrated according to the“imprinting template”,the shortcomings of the research methods of polypharmacokinetics(PPK)and polypharmacodynamics(PPD)of TCM were analyzed,and the differences in the research methodology of dosage-time-effect between multiple components of TCM and single component of TCM were discussed,to clarify the objective necessity that PK/PD model is only applicable to the expression of dosage-time-effect relationship of single component,while the study methodology of PPK/PPD model of the multiple-components of TCM must be established independently,and thereby proposing solutions to the key problems of the integration and simplification of PPK and PPD of component clusters in TCM according to their“imprinting template”and the integration of the non integrable items with power series,so as to lay a theoretical foundation for the research on the demonstrating model of the complex system of the TCM.
作者
贺琪
肖美凤
贺鹏
李文姣
李海英
邓凯文
贺福元
HE Qi-jun;XIAO Mei-feng;HE Peng;LI Wen-jiao;LI Hai-ying;DENG Kai-wen;HE Fu-yuan(Affiliated to Hunan University of Chinese Medicine,Changsha 410007,China;Hunan Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine,Changsha 410208,China;Laboratory of Supramolecular Mechanism and Mathematic-Physics Characterization for Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China;Key Laboratory of Property and Pharmacodynamics of Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,Changsha 410208,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第12期4061-4068,共8页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(82274215)
国家自然科学基金资助项目(81874507)
湖南省重点研发计划(2022SK2014)
湖南省自然科学基金和科药联合基金项目(2021JJ80058,2022JJ30453,2023JJ60124)。
关键词
中药
量-时-效关系
谱动学
谱效动力学
定量药理学
超分子“气析”理论
印迹模板
关键科学问题
traditional Chinese medicine
dosage-time-effect relationship
polypharmacokinetics
polypharmacodynamics
quantitative pharmacology
supramolecular“Qi chromatography”theory
imprinted template
key scientific issue
