摘要
目的探讨传统中药联合^(131)I治疗格雷夫斯甲状腺功能亢进症(简称Graves甲亢)患者的疗效及临床价值。方法回顾性分析2020年3月至2021年7月间常熟市第二人民医院诊治的Graves甲亢患者90例[男39例,女51例;年龄(33.2±7.0)岁],按简单随机法分为A组(30例;采用抗甲状腺药物治疗),B组(30例;采用传统中药治疗),C组(30例;采用传统中药治疗联合^(131)I治疗)。测定治疗前及治疗后1、3、6个月的甲状腺功能指标,包括游离三碘甲状腺原氨酸(FT_(3))、游离甲状腺素(FT_(4))、促甲状腺激素(TSH)及TSH受体抗体(TRAb);测定炎性反应指标,包括C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)。采用单因素方差分析和χ^(2)检验分析数据。结果3组患者治疗前和治疗后1、3、6个月的FT_(3)、FT_(4)、TSH、TRAb、CRP、IL-6和TNF-α水平差异均有统计学意义(F值:193.27~906.11,均P<0.05)。C组的总有效率[100.0%(30/30)]与A组[86.7%(26/30)]、B组[83.3%(25/30)]比较差异均有统计学意义(χ^(2)值:8.24、9.83,P值:0.006、0.037);但A组与B组比较,差异无统计学意义(χ^(2)=3.02,P=0.124)。B组不良反应发生率[46.7%(14/30)]与A组[30.0%(9/30)]比较,差异有统计学意义(χ^(2)=6.59,P=0.042);C组不良反应发生率[13.3%(4/30)]与A组、B组比较差异均有统计学意义(χ^(2)值:12.05、7.20,P值:0.004、0.038)。结论传统中药治疗联合^(131)I治疗Graves甲亢方法疗效确切,建议同行共同研究完善。
Objective To explore the value of traditional Chinese medicine combined with ^(131)I in the treatment of Graves hyperthyroidism.Methods From March 2020 to July 2021,90 patients(39 males,51 females,age(33.2±7.0)years)with Graves hyperthyroidism who were diagnosed and treated in Changshu No.2 People′s Hospital were retrospectively analyzed.Patients were randomly divided into 3 groups(n=30 in each group),including group A who received treatment of antithyroid drugs(ATD),group B who received treatment of traditional Chinese medicine,and group C who received treatment of ^(131)I combined with traditional Chinese medicine.Thyroid function indicators and inflammatory indicators before treatment and 1,3,and 6 months after treatment were determined,including free triiodothyronine(FT_(3)),free thyroxine(FT_(4)),thyroid stimulating hormone(TSH)and TSH receptor antibody(TRAb),and C-reactive protein(CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α).One-way analysis of variance andχ^(2) test were used to analyze data.Results The levels of FT_(3),FT_(4),TSH,TRAb,CRP,IL-6 and TNF-αin group A,B and C before treatment and 1,3,6 months after treatment were significantly different(F values:193.27-906.11,all P<0.05).The total effective rate in group C(100.0%,30/30)was significantly higher than that in group A(86.7%,26/30)or group B(83.3%,25/30;χ^(2) values:8.24,9.83,P values:0.006,0.037),while there was no significant difference between group A and group B(χ^(2)=3.02,P=0.124).The incidence of adverse reactions in group B(46.7%,14/30)was significantly higher than that in group A(30.0%,9/30;χ^(2)=6.59,P=0.042).And the incidence of adverse reaction in group C(13.3%,4/30)was significantly lower than that in group A or group B(χ^(2) values:12.05,7.20,P values:0.004,0.038).Conclusion The curative effect of ^(131)I combined with traditional Chinese medicine is effective and reliable,suggesting that clinical researches should be carried out together and perfected.
作者
张晓懿
朱静
张子文
沈超
朱宝
Zhang Xiaoyi;Zhu Jing;Zhang Ziwen;Shen Chao;Zhu Bao(Depatment of Nuclear Medicine,Changshu No.2 People′s Hospital,Changshu 215500,China;Department of Nuclear Medicine,Nanjing Medical University Affiliated Wuxi People′s Hospital,Wuxi 214023,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2023年第6期360-364,共5页
Chinese Journal of Nuclear Medicine and Molecular Imaging
