摘要
目的探讨不同孕期妊娠妇女尿碘(UIC)与尿碘肌酐比值(UIC/Cr)的临床意义。方法选取于平顶山市第一人民医院2019年2月至2022年5月产前检查的249例妊娠妇女为研究对象,根据不同孕期分为妊娠早期组(72例,孕1~12周)、妊娠中期组(96例,孕13~27周)、妊娠晚期组(81例,孕28~40周)。比较三组甲状腺功能减退症发生率以及入院时UIC、UIC/Cr、甲状腺激素[促甲状腺激素(TSH)、游离三碘甲状腺原氨酸(FT_(3))、游离四碘甲状腺原氨酸(FT_(4))]水平,分析入院时尿碘与尿碘肌酐比值与甲状腺激素水平相关性。结果三组入院时UIC与UIC/Cr的水平比较:妊娠早期组>妊娠中期组>妊娠晚期组(P<0.05);三组入院时血清TSH水平比较:妊娠早期组<妊娠中期组<妊娠晚期组(P<0.05);血清FT_(3)、FT_(4)水平比较:妊娠早期组>妊娠中期组>妊娠晚期组(P<0.05);妊娠早、中、晚期UIC水平、UIC/Cr水平与血清TSH水平呈负相关,与血清FT_(3)、FT_(4)水平呈正相关(P<0.05);三组甲状腺功能减退症发生率比较:妊娠早期组<妊娠中期组<妊娠晚期组(P<0.05)。结论妊娠晚期妇女极易发生甲状腺功能减退症,动态监测UIC与UIC/Cr水平有助于早期预测甲状腺功能减退症,为临床早期预防提供可参考依据。
【Objective】To investigate the clinical significance of urinary iodine(UIC)and the ratio of urinary iodine to creatinine(UIC/Cr)in pregnant women at different stages of pregnancy.【Methods】A total of 249 pregnant women who underwent prenatal examination in our hospital from February 2019 to May 2022 were selected as the research objects,and divided into early pregnancy group(72 cases,1 to 12 weeks of pregnancy)and second pregnancy group(96 cases,13 to 27 weeks of gestation)and third trimester group(81 cases,28 to 40 weeks of gestation)according to different pregnancy periods.The incidence of hypothyroidism and UIC,UIC/Cr,thyroid hormones[thyroid stimulating hormone(TSH),free triiodothyronine(FT3),free tetraiodothyronine(FT4)]on admission were compared among the three groups.The correlation between urinary iodine,the ratio of urinary iodine to creatinine and the level of thyroid hormone at admission was analyzed.【Results】Comparison of UIC and UIC/Cr levels among the three groups on admission:early pregnancy group>second pregnancy group>late pregnancy group(P<0.05);comparison of serum TSH levels among the three groups on admission:early pregnancy group<mid pregnancy group<late pregnancy group(P<0.05);comparison of serum FT3 and FT4 levels:early pregnancy group>second trimester group>late pregnancy group(P<0.05).UIC levels,UIC/Cr levels in early,middle and late pregnancy were negatively correlated with serum TSH levels,and positively correlated with serum FT3 and FT4 levels(P<0.05).The incidence of hypothyroidism among the three groups was compared:early pregnancy group<middle pregnancy group<late pregnancy group(P<0.05).【Conclusion】Women in late pregnancy are prone to hypothyroidism.Dynamic monitoring of UIC and UIC/Cr levels is helpful for early prediction of hypothyroidism and provides a reference for early clinical prevention.
作者
王跃轲
时慧
柴小玉
WANG Yueke;SHI Hui;CHAI Xiaoyu(Department of Laboratory Medicine,the First People's Hospital of Pingdingshan,Pingdingshan,Henan 467000,China)
出处
《中国医学工程》
2023年第6期97-100,共4页
China Medical Engineering
关键词
孕期
妊娠妇女
尿碘
肌酐
甲状腺功能减退症
pregnancy
pregnant women
urinary iodine
creatinine
hypothyroidism
