摘要
目的探讨亮丙瑞林联合知柏降火汤治疗女童中枢性性早熟的临床效果。方法选取2020年1月至2022年1月濮阳市妇幼保健院收治的82例中枢性性早熟女童,按随机数字表法分为对照组和联合组,各41例,对照组接受亮丙瑞林治疗,联合组接受亮丙瑞林联合知柏降火汤治疗。对比两组临床疗效、不良反应、治疗前后中医证候积分、临床症状指标、性激素水平、第二性征等。结果经12个月治疗后,联合组治疗总有效率(92.68%)高于对照组(73.17%)(P<0.05);两组患儿中医证候积分、子宫容积、卵巢容积、卵泡直径及卵泡刺激素、黄体生成素、雌二醇水平均降低,且联合组低于对照组(P<0.05);两组患儿Tanner乳房Ⅱ期占比增加,Ⅳ期占比降低,同时联合组Tanner乳房Ⅱ占比高于对照组(P<0.05)。联合组与对照组不良反应发生率差异无统计学意义(P>0.05)。结论亮丙瑞林联合知柏降火汤可降低女童中枢性性早熟患儿性激素水平,缩小子宫、卵巢容积及卵泡直径,促进乳房转归,疗效显著,安全性可。
Objective To investigate the clinical efficacy of leuprorelin combined with Zhibai Jianghuo decoction in the treatment of central precocious puberty in girls.Methods Eighty-two cases of girls with central precocious puberty admitted to Puyang Maternal and Child Health Hospital from January 2020 to January 2022 were selected and divided into control group and combination group according to the random number table method,with 41 cases in each group.The control group was treated with leuprorelin and the combination group was treated with leuprorelin combined with Zhibai Jianghuo decoction.The clinical efficacy and adverse effects of the two groups were compared,as well as the Chinese medicine evidence score,clinical symptom index,sex hormone level and secondary sexual characteristics before and after treatment.Results After 12 months of treatment,the total effective rate of combination group(92.68%)was higher than that of the control group(73.17%)(P<0.05).The TCM evidence score,uterine volume,ovarian volume,follicle diameter and follicle stimulating hormone,luteinizing hormone and estradiol levels were reduced in both groups,and the combination group was lower than the control group(P<0.05).And the proportion of Tanner breast stageⅡincreased and the proportion of stageⅣdecreased in both groups,while the proportion of Tanner breastⅡwas higher in the combination group than that in the control group(P<0.05).The difference in the incidence of adverse reactions between the combination group and the control group was not statistically significant(P>0.05).Conclusion The combination of leuprorelin and Zhibai Jianghuo decoction can reduce sex hormone levels,reduce uterine and ovarian volume and follicle diameter and promote breast regression in girls with central precocious puberty,with significant efficacy and safety.
作者
史壮丽
张贺
SHI Zhuangli;ZHANG He(Department of Growth and Development,Puyang Maternal and Child Health Hospital,Puyang 457000,China;Department of Pediatrics,the First Affiliated Hospital of Xinxiang Medical College,Xinxiang 453000,China)
出处
《河南医学研究》
CAS
2023年第12期2237-2240,共4页
Henan Medical Research
关键词
中枢性性早熟
女童
亮丙瑞林
知柏降火汤
临床疗效
central precocious puberty
girls
leuprorelin
Zhibai Jianghuo decoction
clinical efficacy
