摘要
为从染木树属(Saprosma)中获取更多有效的化合物,对中国特有的热带药用植物厚梗染木树(Saprosma crassipes)中的化学成分进行分离纯化以及鉴定,增加染木树属化合物多样性。综合利用正相硅胶柱层析、Sephadex LH-20凝胶柱层析、半制备HPLC等色谱分离技术,对该植物的乙醇提取物进行系统的分离纯化;并运用NMR以及质谱鉴定技术鉴定化合物的结构。从厚梗染木树中分离鉴定了8个化合物(11~8),包括2个环烯醚萜苷:车叶草苷(1)、去乙酰基车叶草苷酸(2),1个蒽醌:1,3-二羟基-2-羟甲基蒽醌(3)以及5个甾体类化合物:卡基二醇(4)、9,11-脱氢麦角甾醇过氧化物(5)、过氧化麦角甾醇(6)、羟基烯酮(7)和(3β)-柱头-5,25-二烯-3-醇(8);所有化合物均为首次从厚梗染木树中分离得到,化合物33~8为首次从染木树属中分离得到。
In order to obtain more effective compounds from Saprosma,the chemical components of Saprosma crassipes,a tropical medicinal plant endemic to China,were isolated,purified and identified to increase the diversity of compounds in Saprosma crassipes.The ethanol extracts of the plant were systematically separated and purified by integrating normalphase silica gel column chromatography,Sephadex LH-20 gel column chromatography,and semi-prepared HPLC.The NMR and mass spectrometry were used to identify the structure of compounds.Eight compounds(1-8)were isolated from the stems of Saprosma crassipes,including two cyclic ether terpene glycosides asperuloside(1)and deacetyl asperulosidic acid(2);one anthraquinone 1,3-dihydroxy-2-hydroxymethylanthraquinone(3),and five steroids kakidiol(4),9,11-dehydroergosterol peroxide(5),ergosterol peroxide(6),hydroxyenone(7),and(3β)-stigma-5,25-dien-3-ol(8).All compounds were isolated for the first time from Saprosma crassipes,and the compounds 3-8 were isolated for the first time from the genus Saprosma.
作者
吴美珠
周学明
冯硕
周金琪
楼永浩
WU Meizhu;ZHOU Xueming;FENG Shuo;ZHOU Jinqi;LOU Yonghao(Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Hainan Normal University,Haikou 571158,China;Key Laboratory of Hainan Provincial Tropical Medicinal Phytochemistry,Hainan Normal University,Haikou 571158,China)
出处
《海南师范大学学报（自然科学版）》
CAS
2023年第2期126-130,共5页
Journal of Hainan Normal University（Natural Science）
基金
国家自然科学基金项目(82260831)。
关键词
染木树属
厚梗染木树
化学成分
环烯醚萜苷
甾体
蒽醌
Saprosma
Saprosma crassipes
chemical composition
cyclic etherterpene glycosides
steroids
anthraquinone
