摘要
目的:研究破格救心汤加减治疗脓毒症心肌功能障碍患者的临床疗效。方法:将70例脓毒症心肌功能障碍患者列为试验对象,以随机数字表法将其分为对照组(n=35)、观察组(n=35)。对照组予以西医常规治疗,观察组行破格救心汤加减。比较两组临床治疗效果以及治疗前后心功能指标、血浆脑钠尿肽(BNP)、血清炎症因子水平、肾功能、不良反应发生情况。结果:观察组治疗总有效率94.29%高于对照组74.29%,差异有统计学意义(P<0.05)。观察组治疗后左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、每分心输出量(CO)、BNP、白细胞介素-10(IL-10)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)改善程度均优于对照组(P<0.05)。治疗后两组患者白蛋白(Alb)、血肌酐(Scr)比较,差异无统计学意义(均P>0.05)。观察组在治疗期间出现2例腹泻、1例痛风;对照组在治疗期间出现3例腹泻、1例痛风,两组患者均经对症治疗后好转;两组患者不良反应总发生率比较,差异无统计学意义(P>0.05)。结论:破格救心汤加减治疗脓毒症心肌功能障碍疗效较好,能改善患者心功能、炎症因子水平,促进康复。
Objective:To study clinical effect of modified Poge Jiuxin decoction on septic patients with myocardial dysfunction.Methods:70 patients with septic myocardial dysfunction were selected as the experimental subjects and divided into control group(n=35)and observation group(n=35)according to the random number table.The control group were treated with western medicine,and the observation group treated with modified Poge Jiuxin decoction.The clinical effects,cardiac function indexes,plasma brain natriuretic peptide(BNP),serum inflammatory factor levels,renal function,and incidence of adverse reactions before and after treatment were compared.Results:The total effective rate in the treatment group 94.29%was higher than that in the control group 74.29%,difference statistically significant(P<0.05).After treatment,the indexes of left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),cardiac output per minute(CO),BNP,interleukin-10(IL-10),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were better than those in the control group(P<0.05).After treatment,the data comparisons of albumin(Alb)and serum creatinine(Scr)showed no difference between the two groups(all P>0.05).Two cases of diarrhea one case of gout in the observation group and three cases of diarrhea one case of gout in the control group during the treatment were observed.The symptoms of the two groups were improved after symptomatic treatment.There was no significant difference in the incidence of adverse reactions between the two groups,difference not statistically significant(P>0.05).Conclusion:The modified Poge Jiuxin decoction has significant effect on the treatment of septic patients with myocardial dysfunction,which is conducive to improving cardiac function,levels of inflammatory factors and rehabilitation.
作者
徐爱平
王夜明
贺贤丽
游莎
XU Aiping;WANG Yeming;HE Xianli;YOU Sha(Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan 430015,China)
出处
《陕西中医》
CAS
2023年第7期877-880,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
湖北省卫生健康委员会科研项目(WJ2019F168)。
关键词
心肌功能障碍
脓毒症
破格救心汤
炎症因子
肾功能
不良反应
Myocardial dysfunction
Sepsis
Poge Jiuxin decoction
Inflammatory factor
Kidney function
Adverse effect
