摘要
总结灵芝多糖的抗肿瘤作用机制。灵芝多糖主要是通过提高机体免疫功能从而达到抗肿瘤的效果,而灵芝多糖对体外培养的肿瘤细胞没有直接的抑制作用。灵芝多糖还可通过抑制肿瘤细胞增殖、迁移,诱导肿瘤细胞凋亡,降低肿瘤细胞耐药性和降低化疗药物毒性等途径发挥抗肿瘤作用。灵芝多糖的抗肿瘤作用机制仍有较多争议,尚未达成共识,仍需要更深入的研究来确定其确切的机制和途径。
In this review,the anti-tumor mechanism of Ganoderma lucidum polysaccharides was reviewed.Ganoderma lucidum polysaccharides mainly achieve anti-tumor effect by improving the immune function of the body,while Ganoderma lucidum polysaccharides have no direct inhibitory effect on tumor cells cultured in vitro.Ganoderma lucidum polysaccharides can also play an anti-tumor role by inhibiting tumor cell proliferation and migration,inducing tumor cell apoptosis,reducing tumor cell resistance and reducing the toxicity of chemotherapeutic drugs.The anti-tumor mechanism of Ganoderma lucidum polysaccharides is still controversial and has not yet reached a consensus.Further research is needed to determine its exact mechanism and pathway.
作者
陈起周
欧阳茜茜
罗辉
于丰彦
权维燕
戚怡
CHEN Qizhou;OUYANG Qianqian;LUO Hui;YU Fengyan;QUAN Weiyan;QI Yi(Guangdong Medical University,Zhanjiang Guangdong 524001,China;The Marine Biomedical Research Institute of Guangdong Zhanjiang,Zhanjiang Guangdong 524001,China;The Key Lab of Zhanjiang for R&D Marine Microbial Resources in the Beibu Gulf Rim,Zhanjiang Guangdong 524001,China)
出处
《中医药导报》
2023年第6期159-164,共6页
Guiding Journal of Traditional Chinese Medicine and Pharmacy
基金
湛江市科技计划项目(NO.2020B01383)。
关键词
灵芝多糖
抗肿瘤
作用机制
综述
Ganoderma lucidum polysaccharide
anti-tumor
mechanism of action
review
