摘要
目的分析慢阻塞肺急性加重期采取布地奈德混悬液雾化吸入联合苏黄止咳胶囊治疗的效果。方法研究的开展时间在2019年8月—2022年8月长沙市中医院收治的76例慢阻肺急性加重期患者作为研究对象,按照随机抽签法,将上述患者分为观察组38例,对照组38例。两组患者均采取常规治疗联合布地奈德混悬液吸入治疗,在此基础上观察组采取苏黄止咳胶囊治疗。对比两组的临床疗效。结果从两组的肺功能指标、血清炎症因子水平和不良反应发生情况方面进行对比分析,治疗前的FEV1/FVC、FEV1、PEF和MEF50指标水平进行比较,观察组与对照组差异无统计学意义(P>0.05),治疗前两组血清C反应蛋白(CRP)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)指标水平存在一致性,差异无统计学意义(P>0.05),治疗后,上述指标两组均发生明显变化,FEV1、PEF和MEF50指标两组均升高,观察组高于对照组,CRP、IL-6和TNF-α指标则是两组均降低,且观察组低于对照组,差异均有统计学意义(P<0.05);两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论在慢阻肺急性加重期采取布地奈德混悬液雾化吸入联合苏黄止咳胶囊治疗有着良好的应用优势,联合治疗能够改善肺功能,减轻机体炎症反应,且用药安全性良好,具有推广价值。
Objective To study and analyze the effect of budesonide suspension aerosol inhalation combined with eucalyptus pine-enteric soft capsule in the treatment of acute exacerbation of chronic obstructive pulmonary disease.Methods This study was conducted from August 2019 to August 2022.76 patients with acute exacerbation of COPD admitted of Changsha Central Hospital during this period were selected as the study subjects.According to the method of random drawing,the above patients were divided into observation group(38 cases)and control group(38 cases).Both groups of patients need to take routine treatment combined with inhalation of budesonide suspension.On this basis,the observation group takes eucalyptus pinus enteric-coated soft capsule treatment.The clinical effects of the two groups were compared.Results There was no significant difference between the observation group and the control group in terms of lung function index,serum inflammatory factor level and incidence of adverse reactions.The levels of FEV1/FVC,FEV1,PEF and MEF50 before treatment were compared,and there was no significant difference between the observation group and the control group(P>0.05),and CRP,IL-6 and TNF in the two groups before treatment-αThe level of indicators was consistent,and the difference was not statistically significant(P>0.05).However,after one week of treatment,the above indicators in both groups changed significantly,and the FEV1,PEF and MEF50 indicators in both groups increased.The observation group was higher than the control group,CRP,IL-6 and TNF-αThe index was decreased in both groups,and the observation group was lower than that in the control group,the difference was statistically significant(P<0.05);there was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion In the acute exacerbation of COPD,budesonide suspension aerosol inhalation combined with eucalyptus pine-enteric-coated soft capsule has good application advantages.The combined treatment can improve lung function,reduce the inflammatory reaction of the body,and the drug safety is good,which has the promotion value.
作者
刘俊
黄秋霞
曾晓媛
LIU Jun;HUANG Qiuxia;ZENG Xiaoyuan(Hunan University of Chinese Medicine,Changsha 410208,Hunan,China;Changsha Central Hospital,Changsha 410000,Hunan,China)
出处
《实用中医内科杂志》
2023年第5期90-92,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
湖南省医药卫生科学技术研究项目(2018LDT0023)。
关键词
布地奈德
苏黄止咳胶囊
慢性阻塞性肺疾病
急性加重期
血清炎症因子
肺功能
不良反应
雾化吸入
budesonide
eucalyptus pinus enteric soft capsule
chronic obstructive pulmonary disease
acute exacerbation period
serum inflammatory factors
lung function
adverse reactions
atomization inhalation
