摘要
目的观察氨茶碱联合噻托溴铵治疗支气管哮喘急性发作期的效果及对肺功能和凝血功能的影响。方法选取2019年8月—2021年8月龙岩市第二医院收治的支气管哮喘急性发作期患者80例,采用随机数字表法分为加氨茶碱组和常规用药组,各40例。常规用药组予常规治疗+噻托溴铵吸入粉雾剂治疗,加氨茶碱组在常规用药组基础上加用氨茶碱注射液治疗,2组均连续治疗7 d。比较2组治疗效果,治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))与FEV_(1)/FVC]、凝血功能指标[血浆纤维蛋白原(Fg)、D-二聚体(D-D)、凝血酶时间(TT)和活化部分凝血活酶时间(APTT)]及不良反应。结果加氨茶碱组患者治疗总有效率为95.00%,高于常规用药组的77.50%(χ^(2)=5.165,P=0.023);治疗7 d后,2组FVC、FEV_(1)、FEV_(1)/FVC较治疗前增加,血浆Fg、D-D水平较治疗前降低,TT、APTT较治疗前缩短,且加氨茶碱组变化幅度大于常规用药组(P均<0.01);加氨茶碱组与常规用药组不良反应总发生率(17.50%vs.12.50%)比较差异无统计学意义(χ^(2)=0.392,P=0.531)。结论氨茶碱联合噻托溴铵治疗支气管哮喘急性发作期的效果更佳,对患者肺功能与凝血功能的改善具有积极影响,且联合用药并未增加不良反应发生风险。
Objective To observe the efficacy of aminophylline combined with tiotropium bromide in the treatment of acute exacerbation of bronchial asthma and its impact on pulmonary function and coagulation function.Methods A total of 80 patients with acute exacerbation of bronchial asthma admitted to the Second Hospital of Longyan from August 2019 to August 2021 were selected.Divided into aminophylline group and conventional medication group using random number table method,with 40 cases in each group.The conventional medication group was treated with routine treatment and tiotropium bromide powder for inhalation,while the aminophylline group was treated with aminophylline injection in addition to the conventional medication group.Both groups were treated continuously for 7 days.The therapeutic effect of the two groups were compared,and the pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1))and FEV_(1)/FVC],coagulation function indexes[fibrinogen(Fg),D-dimer(D-D),thrombin time(TT)and activated partial thromboplastin time(APTT)]before and after treatment were compared.And the occurrence of adverse reactions were compared.Results The total effective rate of treatment in the aminophylline group was 95.00%,higher than 77.50%in the conventional medication group(χ^(2)=5.165,P=0.023).After 7 days of treatment,FVC,FEV_(1),and FEV_(1)/FVC in both groups increased compared to before treatment,while plasma Fg and D-D levels decreased compared to before treatment,TT and APTT were shortened compared to before treatment,and the amplitude of changes in the aminophylline group was greater than that in the conventional medication group(P<0.01).There was no statistically significant difference in the total incidence of adverse reactions between the aminophylline group and the conventional medication group(17.50%vs.12.50%,χ^(2)=0.392,P=0.531).Conclusion The combination of aminophylline and tiotropium bromide is more effective on treating acute exacerbation of bronchial asthma.It has a positive impact on the improvement of pulmonary function and coagulation function of patients,and without increase adverse reactions when combined with medication.
作者
丘灿明
刘隽
廖珍珠
QIU Canming;LIU Jun;LIAO Zhenzhu(Department of Respiratory and Critical Care Medicine,the Second Hospital of Longyan,Fujian Province,Longyan 364000,China)
出处
《临床合理用药杂志》
2023年第17期5-8,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
支气管哮喘
急性发作期
氨茶碱
噻托溴铵
治疗效果
肺功能
凝血功能
Bronchial asthma,acute attack period
Aminophylline
Tiotropium bromide
Therapeutic effect
Pulmonary function
Coagulation function
