摘要
目的探讨布地奈德联合加热湿化高频振荡通气治疗重度早产儿呼吸窘迫综合征的临床疗效。方法选取2020年8月至2022年8月于我院接受治疗的重度呼吸窘迫综合征早产儿120例,随机分为观察组和对照组各60例。两组患儿均接受加热湿化高频振荡通气治疗,观察组在此基础上加用布地奈德进行治疗。对比两组患儿临床疗效。比较治疗前以及治疗后两组患儿血气指标、炎症因子及肺功能指标。比较两组患儿并发症发生情况。结果观察组治疗后24 h、72 h PaO_(2)、pH均显著高于对照组,PaCO_(2)、氧合指数、Clara细胞分泌蛋白16(CC16)、骨形态发生蛋白-7(BMP-7)水平均显著低于对照组,差异有统计学意义(P<0.05)。观察组治疗后24 h、72 h达峰时间比(TPEF/TE)、达峰容积比(VPEF/VE)、每公斤体质量潮气量(VT)显著高于对照组,差异有统计学意义(P<0.05)。两组治疗总有效率比较差异无统计学意义(P>0.05)。观察组并发症发生率为11.7%(7/60),显著低于对照组的26.7%(16/60),差异有统计学意义(P<0.05)。结论在重度呼吸窘迫综合征的早产儿治疗中,采用布地奈德联合加热湿化高频振荡的方式能够有效提高临床疗效,并显著改善患儿的血气指标、炎症因子水平及肺功能,降低并发症发生率。
Objective To explore the clinical effect of budesonide combined with heating humidification high-frequency oscillatory ventilation in the treatment of severe premature respiratory distress syndrome.Methods A total of 120 premature infants with severe respiratory distress syndrome who were treated in our hospital from August 2020 to August 2022 were randomly divided into the experimental group(60 cases)and the control group(60 cases)by random number table method.Both groups of children were treated with heating humidification high-frequency oscillatory ventilation,and the experimental group was treated with budesonide on this basis.The clinical effects of the two groups were compared.The blood gas indexes,inflammatory factors and lung function indexes of the two groups were compared before and after treatment.The withdrawal failure and complications of the two groups were compared.Results There was no significant difference in PaO_(2),PaCO_(2),pH,OI,CC16 and BMP-7 levels between the two groups before treatment(P>0.05).After treatment,PaO_(2) and pH in the experimental group were significantly higher than those in the control group,and PaCO_(2),OI,CC16 and BMP-7 levels were significantly lower than those in the control group(P<0.05).After treatment,PaO 2 and pH at each time point in the two groups were significantly higher than those before treatment,and PaCO_(2),OI,CC16 and BMP-7 levels were significantly lower than those before treatment(P<0.05).After treatment,VPEF/VE,VT and TPEF/TE in the experimental group were significantly higher than those in the control group(P<0.05).The effective rate of treatment in the experimental group was 96.7%(58/60),which was not significantly different from 90.0%(54/60)in the control group(P>0.05).The incidence of complications in the experimental group was 11.7%(7/60),which was significantly lower than 26.7%(16/60)in the control group(P<0.05).Conclusion In the treatment of premature infants with severe respiratory distress syndrome,budesonide combined with heating and humidification high-frequency oscillation can effectively improve the clinical efficacy,significantly improve the blood gas index,inflammatory factor level and lung function of the children,and reduce the incidence of complications.
作者
李芳
李娉娉
LI Fang;LI Pingping(Department of Neonatology,Xinxiang Maternal and Child Health Hospital,Xinxiang 453000,China)
出处
《中国中西医结合儿科学》
2023年第3期216-220,共5页
Chinese Pediatrics of Integrated Traditional and Western Medicine
关键词
重度早产儿呼吸窘迫综合征
布地奈德
加热湿化高频振荡通气
Severe premature respiratory distress syndrome
Budesonide
Heating humidification high-frequency oscillation ventilation
