摘要
目的 探讨高压氧辅助治疗对冠心病不稳定型心绞痛患者的GRACE量表评分、脑钠肽前体(Pro-BNP)、C-反应蛋白(CRP)、D-二聚体(D-Dimer)等指标的影响。方法 本研究为随机对照单中心研究,选取2019年1月~2021年5月在解放军总医院第一医学中心住院治疗的冠心病不稳定型心绞痛患者120例,随机数表法分为基础治疗组60例,在基础治疗的基础上给予高压氧(HBO)治疗,为基础治疗+HBO组60例。两组均给予有效的抗血小板聚集、抗凝、扩血管、降脂、降压、降糖,改善微循环等治疗,基础治疗+HBO组在以上治疗基础上加用0.16 MPa高压氧治疗,1 h/d,共10 d。治疗前后检测血清Pro-BNP、CRP及D-Dimer,并进行临床症状、心电图及GRACE量表评分。结果 HBO+基础治疗组可有效的降低患者血清Pro-BNP、CRP及D-Dimer水平,减少胸痛次数、改善心电图及GRACE量表评分,与基础组比较,差异有统计学意义(P <0.05)。结论 高压氧联合基础治疗可显著降低冠心病不稳定型心绞痛患者危险分层相关指标,改善临床症状,有良好的预期防控效果。
Objective To investigate the GRACE score,Pro-BNP,CRP,D-dimer in patients with unstable angina pectoris of coronary heart disease after hyperbaric oxygen adjuvant therapy along with other related risk stratification factors.Methods A total of 120 inpatients from the hyperbaric oxygen treatment center,admitted between January 2019 to May 2021,were selected.These patients were admitted to hospital with unstable angina as the main diagnosis.The patients were randomly divided into two groups using a computer system:60 patient was in the western medicine treatment group,and the other 60 patients were included in the western medicine treatment+HBO group.The western medicine treatment included:blocking the aggregation of resisting platelets,inhibiting down-regulation of coagulation,controlling the decrease of ventricular rate,coronary vasodilation,regulating dyslipidemia,and stable blood pressure control.Fluctuation,regulation of hyperglycemia and other treatments.In addition to the basic treatment,the HBO treatment group was treated with 0.16 MPa hyperbaric oxygen,1 h/d,for a total of 10 d.Venous blood was drawn before and after treatment to detect serum Pro-BNP,CRP and D-Dimer,and clinical symptoms,electrocardiogram and GRACE scale were scored.Results The HBO+western medicine treatment group demonstrated significant reductions in serum levels of Pro-BNP,CRP and D-Dimer.The group also experienced a decrease in the number of chest pains,improvement in ischemic waveform on the ECG,and a significant reduction in the GRACE scale score,which evaluates the degree of risk.These results showed a significant statistical difference compared to the western medicine group(P<0.05).Conclusion HBO combined with western medicine treatment can significantly improve the risk stratification-related factors in patients with unstable angina pectoris,effectively improve clinical symptoms,and have a good expected prevention and control effect.
作者
叶单单
陈静雯
梁慧
相田园
关旭
Ye Dandan;Chen Jingwen;Liang Hui(Department of Hyperbaric Oxygen,the First Medical Center of PLA General Hospital,Beijing 100853,China)
出处
《中华保健医学杂志》
2023年第3期317-320,共4页
Chinese Journal of Health Care and Medicine
