摘要
疫苗使人类在受到病毒感染前,建立起一道安全屏障。疫苗的使用和普及,曾挽救过数以万计人的性命。目前疫苗仍是人类防御病毒最有力的武器,但疫苗的稳定性一直都是各类疫苗生产和储存中需要解决的重要问题。疫苗制剂中有效成分的不稳定性会严重限制其储存和使用。疫苗制剂稳定剂的添加可以使疫苗的稳定性得到明显改善。由于疫苗稳定剂种类繁多,从种类繁多的疫苗稳定剂中筛选最佳稳定剂,会耗费研发人员很多时间、金钱和精力,增加了稳定剂筛选难度。如何快速筛查出合适的疫苗稳定剂是一个亟待解决的重要问题。本文总结了各类稳定剂保持疫苗抗原稳定的机制,汇总了各类疫苗稳定剂的应用现状,分析了未来疫苗稳定剂的发展趋势,希望可以为今后的疫苗研发中稳定剂的选择提供一些有用参考。
Humans will create a safety barrier by Vaccines injection before infected with the virus.The use and popularization of vaccines have saved tens of thousands of lives.By now,vaccines are still the most powerful defense against the virus.However,it is an important issue of vaccines stability to be solved in the production and storage of various vaccines.The instability of the active ingredients in vaccine can severely limit the storage and usage of vaccines.The stability of vaccine can be obviously improved with the addition of stabilizers.Because of various kinds of vaccine stabilizers,it will cost lots of time,money and energy to select the best stabilizer from a wide variety of vaccine stabilizers,which increases the difficulty of screening stabilizer.So it is an important issue needing to be solved about how to quickly screen a suitable vaccine stabilizer.This paper reviews the mechanism of various stabilizers of keeping vaccine antigen stable,summarizes the application of various vaccine stabilizers,analyzes the trend of development in vaccine stabilizers of the future,hoping to provide some useful references for the selection of stabilizer in vaccine research and development.
作者
刘容麟
李岩异
张卫婷
LIU Ronglin;LI Yanyi;ZHANG Weiting(Huabei Pharmaceutical Jintan Biotechnology Co.LTD,Hebei Province,Shijiazhuang050000,China)
出处
《中国当代医药》
CAS
2023年第19期27-30,36,共5页
China Modern Medicine
关键词
蛋白稳定剂
疫苗稳定剂
病毒稳定剂
抗原稳定性
疫苗稳定性
Protein stabilizers
Vaccine stabilizers
Virus stabilizers
Antigen stability
Vaccine stability
