摘要
目的探讨盐酸多奈哌齐联合重复经颅磁刺激对阿尔茨海默病患者的临床效果。方法选取2021年1月—2022年10月临沂市精神卫生中心收治的96例阿尔茨海默病患者作为研究对象,按照随机数表法分为对照组和试验组,每组48例。对照组采用口服盐酸多奈哌齐治疗,试验组在对照组的基础上联合重复经颅磁刺激治疗。比较两组患者治疗前后的认知功能、日常生活活动能力和睡眠质量情况。结果干预前,两组患者简易精神状态检查表(MMSE)比较,差异无统计学意义(P>0.05);干预后,两组患者MMSE评分均高于干预前,且试验组MMSE评分高于对照组,差异有统计学意义(P<0.05)。干预前,两组患者日常生活能力量表(ADL)评分、匹茨堡睡眠质量指数(PSQI)评分比较,差异无统计学意义(P>0.05);干预后,两组患者ADL评分、PSQI评分均低于干预前,且试验组ADL评分、PSQI评分低于对照组,差异有统计学意义(P<0.05)。结论对阿尔茨海默病患者应用盐酸多奈哌齐联合重复经颅磁刺激治疗可有效改善患者的精神状态、日常生活能力以及睡眠质量,值得临床应用。
Objective To explore the clinical effect of donepezil hydrochloride combined with repetitive transcranial magnetic stimulation on patients with Alzheimer disease.Methods 96 patients with Alzheimer disease who were treated in Linyi Mental Health Center from January 2021 to October 2022 were selected as the subjects of this study.They were randomly divided into two groups with 48 patients each.The control group was treated with oral donepezil hydrochloride,and the experimental group was treated with repeated transcranial magnetic stimulation on the basis of the control group.The cognitive function,activities of daily living(ADL)and sleep quality of the two groups were observed before and after treatment.Results Mini-mental State Examination(MMSE)of the two groups before intervention was compared(P>0.05);after the intervention,the MMSE score of patients in the two groups was higher than that before the intervention,and the MMSE score in the experimental group was higher than that in the control group(P<0.05).ADL score and Pittsburgh Sleep Quality Index(PSQI)score between the two groups were compared before intervention,with no significant difference(P>0.05);after the intervention,the ADL score and PSQI score of the two groups were lower than those before the intervention,and the ADL score and PSQI score of the experimental group were lower than those of the control group(P<0.05).Conclusion The application of donepezil hydrochloride combined with repetitive transcranial magnetic stimulation in patients with Alzheimer disease can effectively improve the mental state,daily living ability and sleep quality of patients,which is worthy of clinical application.
作者
耿静
GENG Jing(Department of Neurology,Linyi Mental Health Center,Linyi Shandong 276000,China)
出处
《中华养生保健》
2023年第14期17-20,共4页
CHINESE HEALTH CARE
关键词
盐酸多奈哌齐
重复经颅磁刺激
阿尔茨海默病
donepezil hydrochloride
repetitive transcranial magnetic stimulation
Alzheimer disease
