摘要
目的:分析恙虫病的临床资料和实验室结果,为临床恙虫病合并肝损害治疗提供依据。方法:回顾分析2019年1月—2021年10月在肇庆市第一人民医院住院的97例恙虫病患者的临床资料。根据相关诊断标准把恙虫病患者分为肝损组60例和非肝损组37例,比较两组患者发病至就诊时间、住院时间、白细胞计数(WBC)、嗜酸性粒细胞百分比(EO%)、血小板(PLT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、白蛋白(ALB)之间的差异性;分析恙虫病肝损组患者在治疗前后各指标水平的变化。结果:本地恙虫病以夏秋型为主,容易引起肝损害,发热96%、焦痂或溃疡85.6%是主要临床特征。实验室结果显示恙虫病患者的EO%、ALB水平降低,ALT、AST、尿素氮(BUN)水平不同程度升高;恙虫病肝损组的PLT、ALB水平低于非肝损组,ALT、AST水平高于非肝损组,差异有统计学意义(t=-6.972、-2.152、7.648、9.428,P<0.05);恙虫病肝损组患者冶疗后与治疗前比较,PLT、EO%、ALB水平明显升高,ALT、AST水平明显降低,差异有统计学意义(t=-14.755、-8.099、-5.618、9.518、15.701,P<0.05)。结论:恙虫病临床症状复杂多样,肝损害是恙虫病的常见并发症,实验室指标检查有助于临床医生对恙虫病诊断和病情评估。
Objective:To analyze the clinical data and laboratory results of scrub typhus to provide a basis for the treatment of clinical scrub typhus combined with liver damage.Methods:The clinical data of 97 patients admitted to the hospital with scrub typhus from January 2019 to October 2021 were retrospectively analyzed.Patients with scrub typhus were divided into 60 cases in the liver-damaged group and 37 cases in the non-hepatic-damaged group according to the relevant diagnostic criteria.The differences between the two groups were compared in terms of time from onset to consultation,length of hospital stay,white blood cell count(WBC),eosinophil percentage(EO%),platelets(PLT),glutathione aminotransferase(ALT),glutathione aminotransferase(AST),and albumin(ALB).The changes in the levels of each index were analyzed before and after treatment in patients in the Tsutsugamushi liver damage group.Results:The local tsutsugamushi was predominantly of the summer and autumn type and was prone to liver damage,with fever(96%)and scorching or ulceration(85.6%)being the main clinical features.Laboratory results showed a decrease in EO%and ALB levels and varying increases in ALT,AST,and BUN levels in patients with scrub typhus.The levels of PLT and ALB were lower in the scrub typhus liver-damaged group than in the non-liver-damaged group,and the levels of ALT and AST were higher than in the non-liver-damaged group,with statistically significant differences(t=-6.972,-2.152,7.648,9.428,P<0.05).Patients in the scrub typhus liver damage group showed significantly higher PLT,EO%and ALB levels and significantly lower ALT and AST levels after smelting compared with those before treatment,with statistically significant differences(t=-14.755,-8.099,-5.618,9.518,15.701,P<0.05).Conclusion:The clinical symptoms of scrub typhus are complex and varied,and liver damage is a common complication of scrub typhus.Laboratory index tests help clinicians to diagnose and assess the condition of scrub typhus.
作者
梁凤嫦
黄婷
袁小燕
余世英
Liang Fengchang;Huang Ting;Yuan Xiaoyan(Departmen of Laboratory,Zhaoqing First People’s Hospital,Zhaoqing,Guangdaong,526040,China)
出处
《黑龙江医学》
2023年第14期1724-1726,1729,共4页
Heilongjiang Medical Journal
关键词
恙虫病
肝损害
临床特征
实验室结果
Scrub typhus
Liver damage
Clinical features
Laboratory results
