摘要
目的研究难治性精神分裂症患者接受氯氮平及帕利哌酮治疗的同时增加重复经颅刺激治疗的临床价值。方法选取2021年1月—2023年1月期间临沂市精神卫生中心收治的难治性精神分裂症患者100例,随机分为两组,对照组50例接受氯氮平及帕利哌酮治疗,分析组50例在对照组基础上增加使用重复经颅磁刺激联合治疗,比较两组治疗效果。结果治疗后分析组各项临床症状评分均低于对照组,差异有统计学意义(P<0.05);治疗后分析组各项临床指标评分均优于对照组,差异有统计学意义(P<0.05);治疗后分析组各项生活质量评分均更高于对照组,差异有统计学意义(P<0.05);分析组临床总疗效98.00%高于对照组,差异有统计学意义(χ^(2)=4.891,P<0.05);分析组不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。结论应用重复经颅磁刺激与氯氮平、帕利哌酮联合的方式治疗难治性精神分裂症患者,可提高临床疗效,改善预后,且不会增加不良反应,具有较好安全性。
Objective To study the clinical value of repetitive transcranial stimulation therapy in patients with refractory schizophrenia receiving clozapine and paliperidone.Methods A total of 100 patients with refractory schizophrenia admitted to Linyi Mental Health Center from January 2021 to January 2023 were selected and randomly divided into two groups.50 patients in the control group received clozapine and paliperidone,and 50 patients in the analysis group received repeated transcranial magnetic stimulation combined therapy on the basis of the control group.The therapeutic effects of the two groups were compared.Results After treatment,the scores of clinical symptoms in the analysis group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the scores of clinical indicators in the analysis group were better than those in the control group,and the difference was statistically significant(P<0.05).After treatment,scores of life quality in the analysis group were higher than those in the control group,and the difference was statistically significant(P<0.05).The total clinical efficacy of the analysis group 98.00%was higher than that of the control group,the difference was statistically significant(χ^(2 )=4.891,P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the analysis group and the control group(P>0.05).Conclusion The combination of repetitive transcranial magnetic stimulation,clozapine and paliperidone in the treatment of refractory schizophrenia can improve the clinical efficacy and prognosis without increasing adverse reactions,and has good safety.
作者
胡乃启
刘宗凤
徐运田
HU Naiqi;LIU Zongfeng;XU Yuntian(Psychiatric Ward 1,Linyi Mental Health Center,Linyi,Shandong Province,276000 China)
出处
《系统医学》
2023年第6期73-76,89,共5页
Systems Medicine
关键词
难治性精神分裂症
氯氮平
重复经颅磁刺激
帕利哌酮
Refractory schizophrenia
Clozapine
Repetitive transcranial magnetic stimulation
Paliperidone
